Document Detail

Assessment of ghrelin, GHS-R, GH, and neurohormones in human fetal pituitary glands and central nervous system: an immunohistochemical study.
MedLine Citation:
PMID:  20164039     Owner:  NLM     Status:  MEDLINE    
The aim of this work was evaluation of expression of ghrelin and GHS-R1a receptor in somatotrops and in neuronal cells of brain tissue in the process of human fetal ontogenesis. Relations were also looked for between GHRH and SS in the pituitary and in the CNS neurones of the studied fetuses. The study was based on 8 pituitaries and 8 brains from fetuses in different periods of intrauterine life. The immunocytochemical technique was used. The presence of ghrelin, GHS-R was shown in the glandular part of the pituitary and CNS during the whole period of intrauterine life. Neurohormones in the stalk of the pituitary were found in fetuses from the 32nd week of pregnancy whereas in the CNS neurones these hormones could be detected throughout the whole period of intrauterine life. The results obtained suggest that stimulation of GH secretion by ghrelin is independent of the feedback concentration and these two hormones act like signals of metabolic balance. GH release by ghrelin in fetal life is independent of somatostatin. The hypothalamic-pituitary axis which regulates pulsatile GH release from the pituitary matures functionally in the third trimester of pregnancy independent of the previous anatomical differentiation.
Andrzej Kedzia; Monika Obara-Moszynska; Maria Chmielnicka-Kopaczyk
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society     Volume:  47     ISSN:  1897-5631     ISO Abbreviation:  Folia Histochem. Cytobiol.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2010-02-18     Completed Date:  2010-05-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8502651     Medline TA:  Folia Histochem Cytobiol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  505-10     Citation Subset:  IM    
II Department of Pediatrics, Poznan University of Medical Sciences, Poznan, Poland.
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MeSH Terms
Central Nervous System / embryology,  metabolism*
Ghrelin / biosynthesis*
Growth Hormone / biosynthesis*
Infant, Newborn
Neurotransmitter Agents / biosynthesis*
Pituitary Gland / embryology,  metabolism*
Receptors, Ghrelin / biosynthesis*
Reg. No./Substance:
0/Ghrelin; 0/Neurotransmitter Agents; 0/Receptors, Ghrelin; 9002-72-6/Growth Hormone

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