Document Detail


Assessment of genetic risk factors for thromboembolic complications in adults with idiopathic nephrotic syndrome.
MedLine Citation:
PMID:  23458174     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: Nephrotic syndrome (NS) may occur with acquired hypercoagulability, however, the fact that it is accompanied by an underlying hereditary thrombophilia, especially combined hereditary thrombophilia would lead to thrombotic events. In this study, we aimed to evaluate the contribution of genetic thrombophilia to development of thrombotic events in adult patients with NS.
MATERIAL AND METHODS: Factor V Leiden (FVL), prothrombin, and methylenetetrahydrofolate reductase (MTHFR) gene mutation were studied in 51 newly diagnosed idiopathic NS patients and age- and gender-matched 20 healthy control subjects included in the study. Renal vein Doppler ultrasound was conducted in order to investigate the prevalence of subclinical renal vein thrombosis.
RESULTS: Of 51 patients, 6 (11.8%) were established to have thromboembolic (TE) complications at the time of diagnosis (4 symptomatic, 2 subclinical), and no recurring thrombotic episode was observed. Genetic mutation was established in all patients that were found to have TE complications. Acquired hypercoagulability factors were similar in patients without and with TE complication.
CONCLUSIONS: The coexistence of inherited thrombophilia in NS may facilitate thromboembolic complications. If the cause of thrombosis cannot be explained by the usual factors attributed to the occurrence of thrombosis in NS, screening for the other factors, such as FVL, MTHFR, and prothrombin gene mutation, may be beneficial.
Authors:
Melisa Sahin; Sultan Ozkurt; Nevbahar Akcar Degirmenci; Ahmet Musmul; Gokhan Temiz; Mehmet Soydan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical nephrology     Volume:  79     ISSN:  0301-0430     ISO Abbreviation:  Clin. Nephrol.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-03     Completed Date:  2013-08-23     Revised Date:  2013-11-25    
Medline Journal Info:
Nlm Unique ID:  0364441     Medline TA:  Clin Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  454-62     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / blood
Case-Control Studies
Factor V / genetics
Female
Follow-Up Studies
Genetic Predisposition to Disease
Humans
Immunosuppressive Agents / therapeutic use
Male
Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
Middle Aged
Mutation
Nephrotic Syndrome / complications,  diagnosis,  drug therapy,  genetics*
Prognosis
Prospective Studies
Prothrombin / genetics
Renal Veins* / ultrasonography
Risk Assessment
Risk Factors
Thrombophilia / complications,  diagnosis,  drug therapy,  genetics*
Treatment Outcome
Venous Thromboembolism / diagnosis,  etiology,  genetics*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Immunosuppressive Agents; 0/factor V Leiden; 9001-24-5/Factor V; 9001-26-7/Prothrombin; EC 1.5.1.20/MTHFR protein, human; EC 1.5.1.20/Methylenetetrahydrofolate Reductase (NADPH2)
Comments/Corrections
Comment In:
Clin Nephrol. 2013 Oct;80(4):311   [PMID:  23782547 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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