| Assessment of gastric emptying and duodenal motility upon ingestion of liquid meal using rapid magnetic resonance imaging. | |
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MedLine Citation:
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PMID: 22143884 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Gastric emptying is achieved by cooperation of gastric and duodenal motor activity. Therefore, evaluation of gastric emptying and its associated mechanisms would benefit clinical therapy as well as medical research. Healthy volunteers underwent rapid magnetic resonance imaging (MRI) of the abdomen along the coronal plane after ingestion of liquid meal. The gastric fundus and duodenum area were semi-automatically quantified by house-made segment software. The average gastric fundus area determined by the serosal end in 40 sequential images was reduced to ~81% after 30 min and to ~70% after 60 min of liquid meal ingestion. The average duodenum area also decreased to ~86% after 30 min and to 83% after 60 min. On the other hand, changes in the center of gravity increased to ~5-fold after 30 min and to ~3-fold after 60 min. The mean velocity of the duodenum wall mimicked changes in the center of gravity. The application of metoclopramide, a dopamine D(2) receptor antagonist, accelerated gastric emptying, presumably due to facilitated duodenal activity even immediately after liquid meal ingestion. The ingestion of water caused fast gastric emptying in 30 min, accompanied by high duodenal motility, but it ceased after 60 min, presumably reflecting complete gastric emptying. A rapid MRI scan visualized the association between gastric emptying and duodenum motility that could be modified by calorie and dopaminergic neurotransmission. Changes in the center of gravity and mean velocity of the duodenum wall appear to properly quantify its motility obtained from cine MRI. |
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Authors:
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Hidemo Teramoto; Toshiyasu Shimizu; Hideto Yogo; Yuuta Nishimiya; Shinji Hori; Takashi Kosugi; Shinsuke Nakayama |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-5 |
Journal Detail:
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Title: Experimental physiology Volume: - ISSN: 1469-445X ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9002940 Medline TA: Exp Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1 Kojin Hospital; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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