Document Detail


Assessment of gastric antisecretory effects of phenoxyisobutyrate derivatives in the rat and the mouse.
MedLine Citation:
PMID:  3247588     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
After the observation of a low incidence of gastric carcinoid tumours in rats, but not in mice, given ciprofibrate for 2 years, ciprofibrate and related compounds were investigated for gastric antisecretory activity. A significant inhibition of gastric secretion, similar to that induced by comparable doses of cimetidine, was observed in the fischer rat 1.5 h after a single oral (200 or 500 mg kg-1) or intraduodenal (100 or 300 mg kg-1) administration of ciprofibrate, bezafibrate, and clofibric acid. Ciprofibrate had prolonged antisecretory activity when compared with bezafibrate or ranitidine. Prolonged inhibition of gastric secretion is proposed as the primary cause of gastric carcinoids in the rat, since in a comparative evaluation, antisecretory activity was observed in the rat but not in the mouse.
Authors:
C T Eason; A Pattison; D D Howells; A J Spencer; F W Bonner
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  23     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  1988 Nov 
Date Detail:
Created Date:  1989-06-20     Completed Date:  1989-06-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  1063-71     Citation Subset:  IM    
Affiliation:
Toxicology Dept., Sterling-Winthrop Research Centre, Alnwick, Northumberland, U.K.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Bezafibrate / pharmacology*
Carcinoid Tumor / chemically induced
Clofibrate / analogs & derivatives*,  pharmacology*
Clofibric Acid / analogs & derivatives*,  pharmacology
Gastric Juice / drug effects,  secretion*
Male
Mice
Mice, Inbred Strains
Rats
Rats, Inbred F344
Species Specificity
Stomach Neoplasms / chemically induced
Time Factors
Chemical
Reg. No./Substance:
41859-67-0/Bezafibrate; 52214-84-3/ciprofibrate; 637-07-0/Clofibrate; 882-09-7/Clofibric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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