Document Detail

Assessment of gait parameters and fatigue in MS patients during inpatient rehabilitation: a pilot trial.
MedLine Citation:
PMID:  21076978     Owner:  NLM     Status:  In-Data-Review    
Gait impairment and fatigue are common and disabling problems in multiple sclerosis (MS). Characterisation of abnormal gait in MS patients has been done mainly using observational studies and simple walking tests providing only limited quantitative and no qualitative data, or using intricate and time-consuming assessment procedures. In addition, the correlation of gait impairments with fatigue is largely unknown. The aim of this study was to characterise spatio-temporal gait parameters by a simple and easy-to-use gait analysis system (GAITRite(®)) in MS patients compared with healthy controls, and to analyse changes and correlation with fatigue during inpatient rehabilitation. Twenty-four MS patients (EDSS <6.5) admitted for inpatient rehabilitation and 19 healthy subjects were evaluated using the GAITRite(®) Functional Ambulation System. Between-group differences and changes of gait parameters during inpatient rehabilitation were analysed, and correlation with fatigue, using the Wurzburg Fatigue Inventory for Multiple Sclerosis (WEIMuS), was determined. Compared to healthy controls MS patients showed significant impairments in different spatio-temporal gait parameters, which showed a significant improvement during inpatient rehabilitation. Different gait parameters were correlated with fatigue physical score, and change of gait parameters was correlated with improvement of fatigue. Spatio-temporal gait analysis is helpful to assess specific walking impairments in MS patients and subtle changes during rehabilitation. Correlation with fatigue may indicate a possible negative impact of fatigue on rehabilitation outcome.
Rosaria Sacco; Rita Bussman; Peter Oesch; Jürg Kesselring; Serafin Beer
Related Documents :
10068848 - Effect of aprindine on heart rate variability indices in patients with ischemic heart d...
6998248 - Soluble immune complexes in cerebrospinal fluid of patients with multiple sclerosis and...
20370798 - Safety and cardiovascular behavior during pulmonary function in patients with marfan sy...
12807388 - Native and transformed alpha2-macroglobulin in plasma from patients with multiple scler...
7383088 - Prediction of bcnu pulmonary toxicity in patients with malignant gliomas: an assessment...
2163098 - Absence of circulating antineutrophil cytoplasm antibodies (anca) in severe vasculitis ...
Publication Detail:
Type:  Journal Article     Date:  2010-11-15
Journal Detail:
Title:  Journal of neurology     Volume:  258     ISSN:  1432-1459     ISO Abbreviation:  J. Neurol.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  889-94     Citation Subset:  IM    
Neurological Sciences Department, Second University of Napoli, Naples, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Random Leslie matrices in population dynamics.
Next Document:  Conditional meta-analysis stratifying on detailed HLA genotypes identifies a novel type 1 diabetes l...