| Assessment of the functional significance of coronary lesions using a monorail catheter. | |
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MedLine Citation:
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PMID: 11287712 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Myocardial fractional flow reserve (FFR) < 0.75 is a reliable index of a functionally severe coronary stenosis. FFR is best assessed by a sensor-tipped pressure monitoring guidewire (PW). The purpose of this study was to assess whether a multifunctional probing catheter (MFP), a 3 French dual-lumen monorail catheter, can be used to accurately measure intracoronary pressure and FFR. In 35 lesions (35 patients; learning group), we calculated FFR by both PW (FFRPW) and MFP (FFRMFP). Using ROC analysis, the FFRMFP value of 0.65 had the highest sensitivity with the FFRPW < 0.75. FFRMFP cut-off (0.65) was tested in 40 patients (testing group). In all cases, lumen diameter was documented by an intracoronary ultrasound examination. In the learning group, the FFRPW was 0.82 +/- 0.17 and FFRMFP was 0.70 +/- 0.23 (r = 0.88; p < 0.001). The FFRMFP cut-off value (0.65) correctly predicted the FFRPW in 37/40 cases in the testing group. In the 3 discordant cases, FFR was critical (< 0.65) by MFP and normal (> 0.75) by PW. In all these cases, minimal lumen cross-sectional area was < 2.8 mm2. When FFRMFP is > 0.65, FFRPW is always > 0.75. These data demonstrate that even with larger cross-sectional area than a pressure wire, the MFP catheter can easily and reliably be used to assess the functional severity of coronary stenosis. |
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Authors:
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C Briguori; T Nishida; M Adamian; A Anzuini; N Corvaja; M Carlino; A Colombo |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of invasive cardiology Volume: 13 ISSN: 1042-3931 ISO Abbreviation: J Invasive Cardiol Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-04-05 Completed Date: 2001-06-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8917477 Medline TA: J Invasive Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 279-86 Citation Subset: IM |
Affiliation:
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Centro Cuore Columbus, Via M. Buonarroti, 48, I-20145, Milan, Italy. columbus@micronet.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Coronary Angiography Coronary Circulation* Coronary Disease / diagnosis*, physiopathology Female Heart Catheterization* / instrumentation Humans Male Middle Aged Ultrasonography, Interventional |
| Comments/Corrections | |
Comment In:
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J Invasive Cardiol. 2001 Apr;13(4):287-9
[PMID:
11287713
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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