Document Detail


Assessment of flow-mediated vasodilatation (FMD) of the brachial artery: effects of technical aspects of the FMD measurement on the FMD response.
MedLine Citation:
PMID:  15618057     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: The ability to assess endothelial function non-invasively with B-mode ultrasound has lead to its widespread application in a variety of studies. However, the absolute values obtained using this approach vary considerably across studies. We studied whether technical aspects of the methodology can explain the wide variety in absolute values across studies. METHODS AND RESULTS: A literature search was performed to identify published reports on flow-mediated vasodilatation (FMD) of the brachial artery published between 1992 and 2001. Information on type of equipment (wall track/B-mode), location of the measurement (antecubital fossa/upper arm), occlusion site (lower/upper arm), occlusion duration (min), and occlusion pressure was extracted. Patient characteristics were also extracted. For the healthy populations, mean FMD varied from 0.20 to 19.2%; for the coronary heart disease (CHD) patients FMD varied from -1.3 to 14%; for subjects with diabetes mellitus FMD varied from 0.75 to 12%. Compared with occlusion at the upper arm, lower arm occlusion was related to decreased FMD (mean difference in FMD -2.47%; 95% CI 0.55-4.39). An occlusion duration of > or =4.5 min was related to an increased FMD compared with an occlusion time of < or =4 min (mean difference 1.30%; 95% CI 0.35-2.46). These findings were adjusted for other technical aspects of the methodology and for differences in risk factors between populations. CONCLUSION: Mean FMD differs widely between studies. There is a great overlap between populations (healthy, CHD, diabetics). Our findings suggest that the technical aspects of the measurements, the location, and the duration of the occlusion may explain some of these differences, whereas type of equipment, location of the measurement, and occlusion pressure do not.
Authors:
Michiel L Bots; Jan Westerink; Ton J Rabelink; Eelco J P de Koning
Related Documents :
17280997 - Blood pressure measurement using finger cuff.
12875477 - Measurement of arm blood pressure using different oscillometry manometers compared to a...
8933997 - Evaluation of non-invasive techniques to assess vasoconstriction in healthy volunteers ...
19963727 - Factors affecting the accuracy of volume-oscillometric blood pressure measurement durin...
18705777 - A systematic review of wound cleansing for pressure ulcers.
6645107 - Pressure-velocity relation in the isolated rabbit left ventricle.
Publication Detail:
Type:  Journal Article; Meta-Analysis; Review     Date:  2004-12-01
Journal Detail:
Title:  European heart journal     Volume:  26     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-08     Completed Date:  2005-06-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  England    
Other Details:
Languages:  eng     Pagination:  363-8     Citation Subset:  IM    
Affiliation:
Julius Center for Health Sciences and Primary Care, HP Str. 6.131 University Medical Center, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. m.l.bots@jc.azu.nl
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Brachial Artery / physiology*,  ultrasonography*
Coronary Disease / physiopathology
Diabetic Angiopathies / physiopathology
Endothelium, Vascular / physiology
Humans
Reference Values
Regional Blood Flow
Reproducibility of Results
Ultrasonography / methods
Vasodilation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Left ventricular concentric geometry is associated with impaired relaxation in hypertension: the Hyp...
Next Document:  Urinary albumin excretion is independently associated with carotid and femoral artery atherosclerosi...