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Assessment of flow distribution in the mouse fetal circulation at late gestation using high frequency Doppler ultrasound.
MedLine Citation:
PMID:  24963005     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This study was to evaluate the flow distribution in the mouse fetal circulation at late gestation using high frequency ultrasound. Twelve fetuses (E17.5) from twelve pregnant CD1 mice were studied using 40MHz ultrasound to assess the flow in eleven vessels based on Doppler measurements of blood velocity and M-mode measurements of diameter. Specifically, the intra-hepatic umbilical vein (UVIH), ductus venosus (DV), foramen ovale (FO), ascending aorta (AA), main pulmonary artery (MPA), ductus arteriosus (DA), descending thoracic aorta (DTA), common carotid artery (CCA), inferior vena cava (IVC), and right and left superior vena cavae (RSVC, LSVC) were examined, and anatomically confirmed by micro-CT. The mouse fetal circulatory system was found similar to that of the humans in terms of the major circuit and three shunts, but characterized by bilateral superior vena cavae and a single umbilical artery. The combined cardiac output (CCO) was 1.22±0.05 ml/min, with the left ventricle (flow in AA) contributing 47.8±2.3% and the right ventricle (flow in MPA) 52.2±2.3%. Relative to the CCO, the flow percentages were 13.6±1.0% for the UVIH, 10.4±1.1% for the DV, 35.6±2.4% for the DA, 41.9±2.6% for the DTA, 3.8±0.3% for the CCA, 29.5±2.2% for the IVC, 12.7±1.0% for the RSVC and 9.9±0.9% for the LSVC. The calculated flow percentage was 16.6±3.4% for the pulmonary circulation and 31.2±5.3% for the FO. In conclusion, the flow in mouse fetal circulation can be comprehensively evaluated with ultrasound. The baseline data of the flow distribution in normal mouse fetus serves as the reference range for future studies.
Authors:
Yu-Qing Zhou; Lindsay S Cahill; Michael D Wong; Mike Seed; Christopher K Macgowan; John G Sled
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-24
Journal Detail:
Title:  Physiological genomics     Volume:  -     ISSN:  1531-2267     ISO Abbreviation:  Physiol. Genomics     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815683     Medline TA:  Physiol Genomics     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014, Physiological Genomics.
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