Document Detail


Assessment of fetal neurodevelopment via fetal magnetocardiography.
MedLine Citation:
PMID:  15498544     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fetal magnetocardiography (fMCG) offers unique capabilities for assessment of fetal heart rate (FHR) and fetal behavior, which are fundamental aspects of neurodevelopment. The most important attribute of fMCG for FHR monitoring is its high precision, which allows accurate assessment of beat-to-beat fetal heart rate variability (FHRV), including respiratory sinus arrhythmia. Using mathematical indices to assess FHRV, we find that short- and long-term FHRV both increase during gestation but not in the same manner. The largest increases in short-term FHRV occur during the last trimester, while the largest increases in long-term FHRV occur early on, with smaller changes occurring during the last trimester. The fMCG also allows assessment of fetal activity. This results from the high sensitivity of the signal to the position and orientation of the fetal heart. FMCG actograms are therefore specific for fetal trunk movement, which are thought to be more important than isolated extremity movements and other small fetal movements. The ability to assess FHR, FHRV, and fetal trunk movement simultaneously makes fMCG a valuable tool for neurodevelopment research.
Authors:
Ronald T Wakai
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Experimental neurology     Volume:  190 Suppl 1     ISSN:  0014-4886     ISO Abbreviation:  Exp. Neurol.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-10-22     Completed Date:  2005-02-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370712     Medline TA:  Exp Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S65-71     Citation Subset:  IM    
Affiliation:
Department of Medical Physics, University of Wisconsin-Madison, Madison, WI 53706, USA. rtwakai@wisc.edu
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MeSH Terms
Descriptor/Qualifier:
Electrocardiography / instrumentation,  methods*
Female
Fetal Development / physiology*
Fetal Movement / physiology
Fetus / physiology*
Gestational Age
Heart Rate, Fetal / physiology
Humans
Magnetics*
Nervous System / embryology
Nervous System Physiological Phenomena*
Pregnancy
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Sensitivity and Specificity
Grant Support
ID/Acronym/Agency:
R-01 HL63174/HL/NHLBI NIH HHS; R-01 NS37740/NS/NINDS NIH HHS

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