Document Detail

Assessment of fetal lung maturity by fluorescence polarization in high-risk pregnancies.
MedLine Citation:
PMID:  8445605     Owner:  NLM     Status:  MEDLINE    
Although the validity of amniotic fluid fluorescence polarization (FPOL) has been documented in normal pregnancies, data are lacking on the predictive value of this method in high-risk pregnancies where biochemical maturation of the fetal lung may be altered. In this study, amniotic fluid was obtained from 86 women with pregnancies complicated by insulin-dependent diabetes (42), twin gestation (22), Rh sensitization (13) and known fetal anomalies (9). In all groups, when FPOL was > .280 (immature), phosphatidylglycerol (PG) was always absent and lecithin and sphingomyelin ratio (L/S) was < 2.5:1. When FPOL values were < .260 (mature), PG was always present and L/S was > 2.5 in 45/50 samples. When FPOL values ranged between .260-.280 (intermediate), L/S and PG values varied and were inconsistent. We conclude that FPOL assessment of fetal lung maturity in pregnancies complicated by diabetes, Rh sensitization, twin gestation and fetal anomalies is as accurate a procedure as is fetal lung maturity testing by L/S and PG. In addition, the testing procedure is quicker, more reproducible and, possibly, more reliable.
A T Ruch; R R Lenke; E R Ashwood
Related Documents :
11847525 - Biochemical profile of amniotic fluid for the assessment of fetal and renal development.
6773905 - The epididymal microenvironment: a site of attack for a male contraceptive?
2029765 - The rate and locus of development of rat vallate taste buds.
10938375 - The forms and sources of cytokinins in developing white lupine seeds and fruits.
12581455 - Anti-ce complicating two consecutive pregnancies with increasing severity of haemolytic...
10597875 - Postmenopausal weight status, body composition and body fat distribution in relation to...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  38     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-04-08     Completed Date:  1993-04-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  133-6     Citation Subset:  IM    
Center for Women and Children, Toledo Hospital/Medical College of Ohio.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
4-Chloro-7-nitrobenzofurazan / analogs & derivatives
Amniotic Fluid / chemistry
Fetal Organ Maturity
Fluorescence Polarization*
Fluorescent Dyes
Lung / embryology*
Phosphatidylcholines / analysis
Phosphatidylglycerols / analysis
Pregnancy Complications*
Prospective Studies
Reproducibility of Results
Risk Factors
Sphingomyelins / analysis
Reg. No./Substance:
0/1-acyl-2-(12-((7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)dodecanoyl)phosphatidylcholine; 0/Fluorescent Dyes; 0/Phosphatidylcholines; 0/Phosphatidylglycerols; 0/Sphingomyelins; 10199-89-0/4-Chloro-7-nitrobenzofurazan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Ovarian surgery via pelviscopy.
Next Document:  Colonic surgery in gynecologic oncology. Risk factor analysis.