Document Detail

Assessment of fetal fibronectin in cervical secretion in cases of equivocal rupture of the membranes at term.
MedLine Citation:
PMID:  8604598     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: To evaluate if the presence of fibronectin in cervical secretion might provide information on the natural course of equivocal prelabor rupture of membranes (ROM) at term. METHODS: One hundred and sixteen women with a history of prelabor ROM at term but without visible amniotic fluid leakage were included in the study. The presence of fetal fibronectin in cervical secretion was determined by a commercially available kit (ROM check; limit of detection 100 ng/ml). Women with (n=49) and without (n=67) a positive fibronectin test were compared with regard to time interval between presumed membrane rupture and delivery, mode of delivery and fetal distress rates. RESULTS: There was no significant difference in the time interval between presumed ROM and delivery between those with a negative fibronectin test (median: 80 hours) and those with a positive test (median: 64 hours; p=0.28, Mann-Whitney U-test). Neither were there any differences in complicated delivery or fetal distress rates. CONCLUSION: Determination of fetal fibronectin in cervical secretion with the present method is of limited value in the clinical management of patients with equivocal rupture of the membranes.
H Nisell; K Hagskog; M Westgren
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  75     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-05-13     Completed Date:  1996-05-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  132-4     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Karolinska Insitute, Huddinge, Sweden.
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MeSH Terms
Cervix Uteri / chemistry*,  metabolism
Fetal Distress / metabolism
Fetal Membranes, Premature Rupture / diagnosis*,  metabolism*
Fetus / metabolism*
Fibronectins / analysis*,  metabolism
Labor, Obstetric / metabolism
Predictive Value of Tests
Reg. No./Substance:

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