Document Detail


Assessment of the female fetal DNA concentration in the plasma of the pregnant women as preeclampsia indicator--preliminary report.
MedLine Citation:
PMID:  19632756     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: This research was designed to analyze the presence of fetal female DNA, expressed in copy number, in the plasma of the pregnant woman with preeclampsia-complicated pregnancy. STUDY DESIGN: Twenty-four pregnant women with female fetuses identified by means of ultrasound scanning were enrolled in this pilot study. The study group consisted of 12 pregnant women with symptoms of preeclampsia, with 12 healthy women, matched for gestational age, as controls. RESULTS: Mean DNA number of genomic equivalents per reaction in the group was 201 geq/PCR (from 44.9 to 375) and increased over time after onset of PE, which was the reason for pregnancy termination. In the group of women with preeclampsia, a notably higher DNA copy number in comparison to the control group was noted (p=0.0003 U Mann-Whitney test). CONCLUSIONS: The pilot study presented in this work confirms that also in the case of preeclampsia-complicated pregnancy with female fetuses it is possible to implement the method of fetal DNA quantification. Use of the presented methods confirms that in severe preeclampsia-complicated pregnancies an increase of the number of DNA genomic equivalents per reaction in comparison to the control group is observed. Due to the small study group further research on the described issue is vital, but this study proves that it is also feasible among women carrying female fetuses.
Authors:
Engel Karina; P??onka Tomasz; Marek Bilar; Orzi??ska Agnieszka; Brojer Ewa; Ronin-Walkowska Elzbieta
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-07-25
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  146     ISSN:  1872-7654     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-05     Completed Date:  2010-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  165-8     Citation Subset:  IM    
Affiliation:
Department of Feto-Maternal Medicine, Pomeranian Medical University, 1 Unii Lubelskiej Street, 71-252 Szczecin, Poland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / blood
Case-Control Studies
DNA / blood*
Female
Fetus*
Humans
Infant, Newborn
Pilot Projects
Pre-Eclampsia / blood*,  diagnosis*
Predictive Value of Tests
Pregnancy / blood*
Pregnancy Complications / blood*,  diagnosis*
Sex Characteristics
Chemical
Reg. No./Substance:
0/Biological Markers; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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