Document Detail

Assessment of fatty acid metabolism in taxan-induced myocardial damage with iodine-123 BMIPP SPECT: comparative study with myocardial perfusion, left ventricular function, and histopathological findings.
MedLine Citation:
PMID:  14575384     Owner:  NLM     Status:  MEDLINE    
PATIENTS AND METHODS: Twenty-five patients with non-small-cell lung cancer were treated with taxan combined with carboplatin intravenously for three cycles. Myocardial SPECT imaging using 99mTc-methoxyisobutyl isonitrile (MIBI) and 123I-15-(p-iodophenyl)-3-(R,S)-methylpentadecanoic acid (BMIPP) was performed successively before and after chemotherapy. Regional uptake scores of BMIPP and MIBI were visually assessed and total uptake scores and the number of abnormal segments were calculated. Left ventricular ejection fraction (LVEF) was obtained by first-pass radionuclide angiocardiography using MIBI. Postmortem pathological examination was performed in 5 patients.
RESULTS: Total BMIPP uptake scores after chemotherapy were significantly lower than those before chemotherapy (23.4 +/- 3.4 vs. 26.6 +/- 0.8; p < 0.001). Mean LVEF showed a significant decrease after chemotherapy. Of the 25 patients, 4 exhibited a decrease in LVEF of more than 10%, 1 had a decrease in LVEF to below 50%, and 1 developed congestive heart failure. These 6 patients had significant decreases in total BMIPP uptake scores and increases in the number of abnormal segments as compared with the other 19 patients. Histopathological examination of myocardial tissue showed interstitial edema and disarrayed myocardial cells.
CONCLUSION: Taxan impairs myocardial fatty acid metabolism. 123I-BMIPP myocardial SPECT is useful for evaluating the cardiotoxicity induced by taxan.
Kimimasa Saito; Kan Takeda; Kyoko Imanaka-Yoshida; Hiroshi Imai; Takao Sekine; Yuko Kamikura
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Annals of nuclear medicine     Volume:  17     ISSN:  0914-7187     ISO Abbreviation:  Ann Nucl Med     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-10-24     Completed Date:  2004-06-03     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  8913398     Medline TA:  Ann Nucl Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  481-8     Citation Subset:  IM    
Department of Pulmonology, Yamada Red Cross Hospital, Mie, Japan.
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MeSH Terms
Antineoplastic Agents, Phytogenic / adverse effects,  therapeutic use
Cardiomyopathies / diagnosis,  etiology*,  radionuclide imaging*
Fatty Acids / diagnostic use*,  metabolism*
Iodine Radioisotopes / diagnostic use
Iodobenzenes / diagnostic use*
Lung Neoplasms / drug therapy
Middle Aged
Paclitaxel / adverse effects*,  therapeutic use
Radiopharmaceuticals / diagnostic use
Stroke Volume
Taxoids / adverse effects*,  therapeutic use
Technetium Tc 99m Sestamibi / diagnostic use
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Fatty Acids; 0/Iodine Radioisotopes; 0/Iodobenzenes; 0/Radiopharmaceuticals; 0/Taxoids; 109581-73-9/Technetium Tc 99m Sestamibi; 116754-87-1/iodofiltic acid; 15H5577CQD/docetaxel; 33069-62-4/Paclitaxel

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