| Assessment of exposure to opiates and cocaine during pregnancy in a Mediterranean city: preliminary results of the "Meconium Project". | |
| | |
MedLine Citation:
|
PMID: 15923097 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
For the first time in Europe, the "Meconium Project" aimed to estimate the prevalence of drug use by pregnant women and the effects of exposure to illicit drugs during pregnancy on the fetus and infant. Between October 2002 and February 2004, 1151 (79%) dyads among the 1439 mother-infant dyads from the Hospital del Mar, Barcelona, Spain, met eligibility criteria and agreed to participate in the study. We present preliminary results on the first 830 meconium samples and 549 mother-infant dyads, for which statistical analysis of socio-economic and demographic characteristics and newborn somatometry was completed. The meconium analysis showed an overall 7.9% positivity for drugs of abuse, with 6-monoacetylmorphine and cocaine being the analytes, most frequently found in samples positive for opiates and cocaine. Structured interview disclosed 1.3, 1.8 and 1.3% of mothers exposed to opiates, cocaine and both drugs, while only one mother declared ecstasy consumption. Meconium analysis showed that prevalence of opiates, cocaine and combined drugs exposure was 8.7, 4.4 and 2.2%, respectively, and confirmed the case of ecstasy use. Arecoline, the main areca nut alkaloid, was found in meconium specimens from four Asiatic newborns, whose mothers declared beetle nut consumption during pregnancy. Parental ethnicity was not associated with drug use, nor was the social class, although a higher tendency toward drug consumption was observed in professional and partly skilled mothers. Drug consuming mothers showed a higher number of previous pregnancies and abortions (p<0.05) when compared to non-consumer mothers (meconium negative test), probably due to a lack of family planning. Consumption of opiates and cocaine during pregnancy was associated with active tobacco smoking, a higher number of smoked cigarettes and cannabis use. Exposure status and smoking behavior correlated with significantly lower birth weight in newborns from mothers exposed only to cocaine and to opiates and cocaine simultaneously. Of the four newborns exposed to arecoline, one showed a low birth weight, low intrauterine growth, hyporeflexia and hypotonia. |
| | |
Authors:
|
Simona Pichini; Carme Puig; Piergiorgio Zuccaro; Emilia Marchei; Manuela Pellegrini; Janeth Murillo; Oriol Vall; Roberta Pacifici; Oscar García-Algar |
Related Documents
:
|
19183137 - A metric of maternal prenatal risk drinking predicts neurobehavioral outcomes in presch... 9088547 - Effects of interactions between pasteurella haemolytica and bordetella parapertussis on... 8879287 - Increased carbohydrate-deficient transferrin during pregnancy: relation to sex hormones. 15846507 - Glucocorticoid programming of adult disease. 1624977 - Community health nursing visits for at-risk women and infants. 20961197 - Application of proteomics to prenatal screening and diagnosis for aneuploidies. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Forensic science international Volume: 153 ISSN: 0379-0738 ISO Abbreviation: Forensic Sci. Int. Publication Date: 2005 Oct |
Date Detail:
|
Created Date: 2005-07-25 Completed Date: 2005-09-22 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7902034 Medline TA: Forensic Sci Int Country: Ireland |
Other Details:
|
Languages: eng Pagination: 59-65 Citation Subset: IM |
Affiliation:
|
Drug Research and Evaluation Department, Istituto Superiore di Sanità, Rome, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abortion, Induced
/
statistics & numerical data Adult Arecoline / analysis Body Height Cholinergic Agonists / analysis Cocaine / analysis* Dopamine Uptake Inhibitors / analysis* Female Forensic Medicine Gravidity Hallucinogens / analysis Humans Infant, Low Birth Weight Infant, Newborn Italy / epidemiology Marijuana Smoking / epidemiology Maternal-Fetal Exchange* Meconium / chemistry* N-Methyl-3,4-methylenedioxyamphetamine / analysis Narcotics / analysis* Pregnancy Smoking / epidemiology Spain / epidemiology Substance Abuse Detection Substance-Related Disorders / diagnosis |
| Chemical | |
Reg. No./Substance:
|
0/Cholinergic Agonists; 0/Dopamine Uptake Inhibitors; 0/Hallucinogens; 0/Narcotics; 42542-10-9/N-Methyl-3,4-methylenedioxyamphetamine; 50-36-2/Cocaine; 63-75-2/Arecoline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Concentration of drugs in blood of suspected impaired drivers.
Next Document: A case of osteoma with cholesteatoma in the external auditory canal.