Document Detail


Assessment of exposure to PCB 153 from breast feeding and normal food intake in individual children using a system approach model.
MedLine Citation:
PMID:  22051344     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Investigators have typically relied on a single or few discrete time points as measures of polychlorinated biphenyl (PCB) body burden, however health effects are more likely to be the result of integrative exposure in time, optionally expressed as an area under the time curve (AUC) of PCB serum concentration. Using data from a subgroup of 93 infants from a birth cohort in eastern Slovakia-a region highly polluted by PCBs-we fit a system type model, customized to our longitudinal measures of serum PCB concentrations in cord, 6, 16, and 45 month blood specimens. The most abundant congener, PCB 153, was chosen for modeling purposes. In addition to currently used methods of exposure assessment, our approach estimates a concentration time profile for each subject, taking into account mean residence time of PCB 153 molecules in the body, duration of breast feeding, hypothetical PCB 153 concentration in steady-state without breast feeding and alternately without normal food intake. Hypothetical PCB 153 concentration in steady-state without normal food intake correlates with AUC (r=0.84, p<0.001) as well as with duration of breast feeding (r=0.64, p<0.001). It makes possible to determine each subject's exposure profile expressed as AUC of PCBs serum concentration with a minimum model parameters. PCB body burden in most infants was strongly associated with duration of breast feeding in most, but not all children, was apparent from model output.
Authors:
Tomáš Trnovec; Ladislav Dedík; Todd A Jusko; Kinga Lancz; Lubica Palkovičová; Anton Kočan; Eva Šovčíková; Soňa Wimmerová; Juraj Tihányi; Henrieta Patayová; Irva Hertz-Picciotto
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2011-11-01
Journal Detail:
Title:  Chemosphere     Volume:  85     ISSN:  1879-1298     ISO Abbreviation:  Chemosphere     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-21     Completed Date:  2012-03-08     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0320657     Medline TA:  Chemosphere     Country:  England    
Other Details:
Languages:  eng     Pagination:  1687-93     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
Slovak Medical University, Limbová 12, 83303 Bratislava, Slovakia. tomas.trnovec@szu.sk
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MeSH Terms
Descriptor/Qualifier:
Area Under Curve
Breast Feeding
Child, Preschool
Cohort Studies
Eating
Environmental Exposure*
Humans
Infant
Longitudinal Studies
Models, Theoretical*
Polychlorinated Biphenyls / blood*
Grant Support
ID/Acronym/Agency:
R01-CA096525/CA/NCI NIH HHS; Z99 ES999999/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Polychlorinated Biphenyls
Comments/Corrections

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