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Assessment of experimental saccular aneurysm using selective angiography in common carotid artery of rabbits.
MedLine Citation:
PMID:  21189992     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
In order to study the treatment of aneurysms, the technique of making experimental aneurysms in laboratory animals must be established. In our study, to examine the feasibility of making experimental aneurysm and selective angiography on the common carotid artery in rabbits and to determine the size of experimental aneurysm after surgery, saccular aneurysms were fashioned on the right common carotid artery in 17 rabbits using a vein pouch technique. Selective angiography of the common carotid artery was performed immediately after surgery, and at 1 week, 4 weeks, and 8 weeks after surgery. Also, histological changes in the aneurysms were observed. In 16 rabbits with established successful experimental aneurysm, no differences were found in diet intake and behavior before and after surgery. The patency of the carotid artery was confirmed by selective angiography. The average size of the aneurysm immediately after surgery was similar to that of 1 week postoperatively in selective angiography, however it increased with time at 4weeks and 8 weeks. Histologically, infiltration of inflammatory cells and hemorrhage were found at the junction of the carotid artery and the vein pouch at 1 week, which disappeared at 4 weeks and 8 weeks. This study suggests experimental saccular aneurysm using the vein pouch technique might form aneurysms similar to that of the human in its properties such as increment of size, and selective angiography might be suitable for assessment of experimental aneurysm. Therefore, this animal model may be suitable for investigating new treatment methodologies for human aneurysms.
Authors:
Dong Woo Chang; Bong Kyung Kim; Jae Hoon Shin; Young Min Yoon; Seung Hyun Oh; Yeo Sung Yoon; Sung-Hyeok Hong; Ki Chang Lee; Young Won Lee; Kang Moon Seo; Oh-Kyeong Kweon; Jung Hee Yoon; Nam-Shik Shin; Kyu Ho Lee; Jun-Gyo Suh; Je Kyung Seong
Publication Detail:
Type:  Journal Article     Date:  2010-06-30
Journal Detail:
Title:  Anatomy & cell biology     Volume:  43     ISSN:  2093-3673     ISO Abbreviation:  Anat Cell Biol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-12-30     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101531987     Medline TA:  Anat Cell Biol     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  118-24     Citation Subset:  -    
Affiliation:
Department of Veterinary Radiology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea.
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