| Assessment of the esophageal pressure in gastroesophageal reflux disease by the local regression. | |
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MedLine Citation:
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PMID: 16078624 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gastroesophageal reflux disease (GERD) is one of the most prevalent gastrointestinal diseases. It is characterized by excessive reflux of gastric content (acid, pepsin, etc.) into the esophagus causing symptoms (heartburn, acid regurgitation, etc.) and mucosal inflammation and injuries. GERD occurs when the lower esophageal sphincter (LES) has a low resting pressure and stomach contents leak back, or reflux, into the esophagus. Therefore, the accurate measurement of the LES pressure is of great importance for the diagnosis of GERD. The LES pressure signal, involving severe respiratory contamination and motion artifacts, demands specific capabilities not provided by conventional data analysis methods. Recently, local regression has proved to be a very attractive technique to the nonparametric regression in statistics. In this contribution we apply the ideas of local regression to develop strategies for selecting smoothing parameters of local linear squares estimators, and present its application on the extraction of the LES pressure in GERD. The results from both extensive simulations and real data demonstrate the ability of local regression to characterize the LES pressure, which is consistent with the clinical observation. |
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Authors:
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Hualou Liang; J D Z Chen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of biomedical engineering Volume: 33 ISSN: 0090-6964 ISO Abbreviation: Ann Biomed Eng Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-08-04 Completed Date: 2005-10-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0361512 Medline TA: Ann Biomed Eng Country: United States |
Other Details:
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Languages: eng Pagination: 847-53 Citation Subset: IM |
Affiliation:
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School of Health Information Sciences, University of Texas at Houston, 7000 Fannin, Suite 600, Houston, Texas 77030, USA. hualou.liang@uth.tmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Computer Simulation* Esophagogastric Junction / pathology, physiopathology* Gastroesophageal Reflux / pathology, physiopathology* Humans Models, Biological* Pressure Regression Analysis |
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