| Assessment of the energetic role of endogenous substrates in the tail artery of rat by means of enzyme inhibitors. | |
| | |
MedLine Citation:
|
PMID: 8774080 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The rat tail artery during a 180 min incubation period in a medium containing glucose plus oxfenicine (an inhibitor of fatty acid oxidation) did not show changes in the contractile responses to adrenaline. In a substrate-free medium the extent of the contractions underwent a slight decrease during the last 60 min of incubation. When the substrate-free medium contained 2-deoxyglucose (an inhibitor of glycolysis and glycogenolysis) or oxfenicine, the decline of the contractile activity developed faster and attained a similar extent with each inhibitor. When the substrate-free medium contained 2-deoxyglucose together with oxfenicine or methylpalmoxirate (an inhibitor of fatty acid oxidation) the arteries displayed a pronounced and early fall in the contraction strength. These data suggest that in the presence of glucose the reserve substrates are not necessary as fuel source for the arterial contractions. However, in substrate-free conditions they constitute an important energy source. Furthermore, glycogen and triacylglycerol share the supply of energy and there does not seem to be any other reserve material in the smooth muscle of the rat tail artery. |
| | |
Authors:
|
E A Savino; A Varela; M Carregal |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Revista española de fisiología Volume: 52 ISSN: 0034-9402 ISO Abbreviation: Rev. Esp. Fisiol. Publication Date: 1996 Mar |
Date Detail:
|
Created Date: 1996-11-21 Completed Date: 1996-11-21 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0404475 Medline TA: Rev Esp Fisiol Country: SPAIN |
Other Details:
|
Languages: eng Pagination: 9-13 Citation Subset: IM |
Affiliation:
|
Cátedra de Fisiología, Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antimetabolites / pharmacology Arteries / metabolism Deoxyglucose / pharmacology Energy Metabolism / drug effects, physiology* Enzyme Inhibitors / pharmacology* Epinephrine / pharmacology Epoxy Compounds / pharmacology Glucose / pharmacology Glycine / analogs & derivatives, pharmacology Hypoglycemic Agents / pharmacology Male Muscle, Smooth, Vascular / enzymology* Propionates / pharmacology Rats Rats, Wistar Substrate Specificity Tail / blood supply* Vasoconstriction / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
|
0/Antimetabolites; 0/Enzyme Inhibitors; 0/Epoxy Compounds; 0/Hypoglycemic Agents; 0/Propionates; 154-17-6/Deoxyglucose; 50-99-7/Glucose; 51-43-4/Epinephrine; 56-40-6/Glycine; 69207-52-9/methyl 2-tetradecylglycidate; 938-97-6/4-hydroxyphenylglycine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of hypothermic perfusion on pulmonary circulation in isolated rabbit lung.
Next Document: Characterization and quantification of apolipoprotein E in the genetically hypercholesterolemic rat ...