| Assessment of the emergence of Alzheimer's disease following coronary artery bypass graft surgery or percutaneous transluminal coronary angioplasty. | |
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MedLine Citation:
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PMID: 16131734 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Post-Operative Cognitive Decline (POCD) is a complication of Coronary Artery Bypass Graft (CABG) surgery and is consistent with reduced neuronal reserve. We performed a retrospective cohort analysis of Veterans Affairs (VA) patients undergoing CABG or PTCA between October 1, 1996 and September 30, 1997 to examine if CABG surgery is associated with the earlier emergence of cognitive impairment such as Alzheimer's Disease (AD). The emergence of dementia following CABG surgery was compared to dementia in a cardiac population undergoing percutaneous transluminal coronary angioplasty (PTCA). Patients were followed from the date of their procedure until September 30, 2002, the diagnosis of Alzheimer's disease or death. Cox proportional hazards models were used to compare the risk of AD development. Patients analyzed were > or = 55 yrs old without baseline dementia. The results show that a total of 119 patients (CABG = 78; PTCA = 41) developed AD during the follow-up period. The adjusted risk of AD associated with CABG versus PTCA was 1.71 (95% CI, 1.02 to 2.87; p = 0.04). These results suggest that patients undergoing CABG surgery were at increased risk for the emergence of AD than those undergoing PTCA. These data support the hypothesis that CABG surgery is associated with a reduced neuronal reserve in an aging population. |
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Authors:
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Todd A Lee; Benjamin Wolozin; Kevin B Weiss; Martin M Bednar |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of Alzheimer's disease : JAD Volume: 7 ISSN: 1387-2877 ISO Abbreviation: J. Alzheimers Dis. Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-08-31 Completed Date: 2005-11-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9814863 Medline TA: J Alzheimers Dis Country: Netherlands |
Other Details:
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Languages: eng Pagination: 319-24 Citation Subset: IM |
Affiliation:
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Midwest Center for Health Services and Policy Research, Hines VA Hospital, Hines, IL, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Alzheimer Disease / etiology*, physiopathology* Angioplasty, Balloon* Cognition Disorders / diagnosis, etiology Cohort Studies Coronary Artery Bypass* Female Follow-Up Studies Humans Male Middle Aged Postoperative Complications* Retrospective Studies |
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