Document Detail


Assessment of the emergence of Alzheimer's disease following coronary artery bypass graft surgery or percutaneous transluminal coronary angioplasty.
MedLine Citation:
PMID:  16131734     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Post-Operative Cognitive Decline (POCD) is a complication of Coronary Artery Bypass Graft (CABG) surgery and is consistent with reduced neuronal reserve. We performed a retrospective cohort analysis of Veterans Affairs (VA) patients undergoing CABG or PTCA between October 1, 1996 and September 30, 1997 to examine if CABG surgery is associated with the earlier emergence of cognitive impairment such as Alzheimer's Disease (AD). The emergence of dementia following CABG surgery was compared to dementia in a cardiac population undergoing percutaneous transluminal coronary angioplasty (PTCA). Patients were followed from the date of their procedure until September 30, 2002, the diagnosis of Alzheimer's disease or death. Cox proportional hazards models were used to compare the risk of AD development. Patients analyzed were > or = 55 yrs old without baseline dementia. The results show that a total of 119 patients (CABG = 78; PTCA = 41) developed AD during the follow-up period. The adjusted risk of AD associated with CABG versus PTCA was 1.71 (95% CI, 1.02 to 2.87; p = 0.04). These results suggest that patients undergoing CABG surgery were at increased risk for the emergence of AD than those undergoing PTCA. These data support the hypothesis that CABG surgery is associated with a reduced neuronal reserve in an aging population.
Authors:
Todd A Lee; Benjamin Wolozin; Kevin B Weiss; Martin M Bednar
Related Documents :
10345964 - Obstacles to early discharge after cardiac surgery.
17670104 - Preoperative beta-blocker therapy in coronary artery bypass surgery: a propensity score...
9108754 - Gastrointestinal complications following cardiac surgery. an analysis of 1477 cardiac s...
14627974 - Conservative vs. invasive treatment of aortocoronary saphenous vein graft aneurysms: tr...
11579364 - Outcomes after emergency department discharge with a primary diagnosis of heart failure.
17632354 - Surgical strategies for brachial plexus polio-like paralysis.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of Alzheimer's disease : JAD     Volume:  7     ISSN:  1387-2877     ISO Abbreviation:  J. Alzheimers Dis.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-31     Completed Date:  2005-11-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9814863     Medline TA:  J Alzheimers Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  319-24     Citation Subset:  IM    
Affiliation:
Midwest Center for Health Services and Policy Research, Hines VA Hospital, Hines, IL, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Alzheimer Disease / etiology*,  physiopathology*
Angioplasty, Balloon*
Cognition Disorders / diagnosis,  etiology
Cohort Studies
Coronary Artery Bypass*
Female
Follow-Up Studies
Humans
Male
Middle Aged
Postoperative Complications*
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Alzheimer's disease amyloid-beta peptide modulates apolipoprotein E isoform specific receptor bindin...
Next Document:  Neurological soft signs are associated with APOE genotype, age and cognitive performance.