Document Detail

Assessment of the efficacy and safety of nimesulide vs naproxen in paediatric patients with respiratory tract infections. A comparative single-blind study.
MedLine Citation:
PMID:  7506179     Owner:  NLM     Status:  MEDLINE    
A total of 99 paediatric patients (57 male, 42 female) aged 1 to 12 years, weighing 10 to 40kg and with acute pharyngo-amygdalitis were enrolled in a single-blind study to assess the efficacy and tolerability of nimesulide in comparison with naproxen when both drugs were administered over an 8-day treatment period. Among the 2 treatment groups comprising 99 evaluable patients, demographic analysis of age, weight and height did not reveal statistically significant differences. Evaluation of fever, pain, inflammation and nasal obstruction over the 8-day treatment period showed a significant improvement in these parameters for those patients treated with nimesulide when compared with naproxen from day 1, with remission of symptoms starting from day 3. These findings were complemented by a superior tolerability profile reported for nimesulide-treated patients. In conclusion, nimesulide appears to be a safe and effective treatment for paediatric patients with pharyngo-amygdalitis and it has shown superior efficacy and tolerability when compared with naproxen.
L E Salmòn Rodriguez; H A Arista Viveros; M E Lujan; R M Maciel; C L Trujillo; E Lopez
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Drugs     Volume:  46 Suppl 1     ISSN:  0012-6667     ISO Abbreviation:  Drugs     Publication Date:  1993  
Date Detail:
Created Date:  1994-02-04     Completed Date:  1994-02-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600076     Medline TA:  Drugs     Country:  NEW ZEALAND    
Other Details:
Languages:  eng     Pagination:  226-30     Citation Subset:  IM    
Unidad de Pediatria, Hospital General de Mexico, Mexico City.
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MeSH Terms
Acute Disease
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Child, Preschool
Naproxen / therapeutic use*
Respiratory Tract Infections / drug therapy*
Single-Blind Method
Sulfonamides / therapeutic use*
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Sulfonamides; 22204-53-1/Naproxen; 51803-78-2/nimesulide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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