| Assessment of the effects of subthalamic stimulation in Parkinson disease patients by artificial neural network. | |
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MedLine Citation:
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PMID: 19163765 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study aims at applying an artificial neural network for the evaluation of the effects of deep brain stimulation (DBS) of the subthalamic nucleus (STN) on Parkinson disease (PD) patients with and without medication. A sample of 15 PD patients who have undergone STN DBS were evaluated under four test conditions: medication off and stimulation off (mof-sof), medication off and stimulation on (mof-son), medication on and stimulation off (mon-sof) and medication on and stimulation on (mon-son). A control group with 30 subjects was also evaluated. Principal component analysis (PCA) was applied on vertical ground reaction force (vGRF) and the first six principal component scores (PC score) were obtained in both groups. Those PCs scores were used as input in a probabilistic neural network (PNN). PNN presented satisfactory classification performance in the separation of controls and PD with 90.1% accuracy, 69.2% sensitivity and 100% specificity. The stimulation mof-son and mon-son conditions presented better results compared to mon-sof. In the mof-son condition, 41.7% were classified as normal, while further enhancement (63.3%) was given by the mon-son condition. These results indicated the potentiality of PNN to quantitatively evaluate treatment effects. Furthermore, STN DBS shows improvement on vGRF pattern in PD patients, most substantially when used with medication. |
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Authors:
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A S Muniz; F F Nobre; H Liu; K E Lyons; R Pahwa; W Liu; J Nadal |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference Volume: 2008 ISSN: 1557-170X ISO Abbreviation: Conf Proc IEEE Eng Med Biol Soc Publication Date: 2008 |
Date Detail:
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Created Date: 2009-02-16 Completed Date: 2009-05-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101243413 Medline TA: Conf Proc IEEE Eng Med Biol Soc Country: United States |
Other Details:
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Languages: eng Pagination: 4700-3 Citation Subset: IM |
Affiliation:
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Biomedical Engineering Program, COPPE, Federal University of Rio de Janeiro, Brazil P.O. Box 68.510, 21941-972 - BRAZIL. adriane@peb.ufrj.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Algorithms Computer Simulation Electric Stimulation Therapy / methods* Female Humans Male Middle Aged Motor Activity / physiology* Neural Networks (Computer) Parkinson Disease / therapy* Probability Reaction Time / physiology* Subthalamic Nucleus / physiology* Task Performance and Analysis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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