Document Detail

Assessment of the effects of physical training in patients with chronic heart failure: the utility of effort-independent exercise variables.
MedLine Citation:
PMID:  19834732     Owner:  NLM     Status:  MEDLINE    
Traditionally, the effects of physical training in patients with chronic heart failure (CHF) are evaluated by changes in peak oxygen uptake (peak VO(2)). The assessment of peak VO(2), however, is highly dependent on the patients' motivation. The aim of the present study was to evaluate the clinical utility of effort-independent exercise variables for detecting training effects in CHF patients. In a prospective controlled trial, patients with stable CHF were allocated to an intervention group (N = 30), performing a 12-week combined cycle interval and muscle resistance training program, or a control group (N = 18) that was matched for age, gender, body composition and left ventricular ejection fraction. The following effort-independent exercise variables were evaluated: the ventilatory anaerobic threshold (VAT), oxygen uptake efficiency slope (OUES), the V(E)/VCO(2) slope and the time constant of VO(2) kinetics during recovery from submaximal constant-load exercise (tau-rec). In addition to post-training increases in peak VO(2) and peak V(E), the intervention group showed significant within and between-group improvements in VAT, OUES and tau-rec. There were no significant differences between relative improvements of the effort-independent exercise variables in the intervention group. In contrast with VAT, which could not be determined in 9% of the patients, OUES and tau-rec were determined successfully in all patients. Therefore, we conclude that OUES and tau-rec are useful in clinical practice for the assessment of training effects in CHF patients, especially in cases of poor subject effort during symptom-limited exercise testing or when patients are unable to reach a maximal exercise level.
Hareld M C Kemps; Wouter R de Vries; Sandor L Schmikli; Maria L Zonderland; Adwin R Hoogeveen; Eric J M Thijssen; Goof Schep
Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-10-16
Journal Detail:
Title:  European journal of applied physiology     Volume:  108     ISSN:  1439-6327     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-20     Completed Date:  2010-04-08     Revised Date:  2010-05-24    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  469-76     Citation Subset:  IM    
Department of Cardiology, M?xima Medical Centre, Veldhoven, The Netherlands.
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MeSH Terms
Chronic Disease
Exercise / physiology*
Exercise Test
Heart Failure / physiopathology*
Middle Aged
Oxygen Consumption / physiology
Prospective Studies
Pulmonary Gas Exchange / physiology
Pulmonary Ventilation / physiology
Resistance Training*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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