Document Detail

Assessment of diffusion tensor MR imaging (DTI) in liver fibrosis with minimal confounding effect of hepatic steatosis.
MedLine Citation:
PMID:  24733754     Owner:  NLM     Status:  Publisher    
PURPOSE: Given the potential confounding effect of fat on apparent diffusion coefficient (ADC) in the liver, we have assessed diffusion tensor imaging in liver fibrosis with minimal effect of fat on ADC and fractional anisotropy (FA).
METHODS: Thirty-six mice were used, among which 20 mice were CCl4 treated for fibrosis induction. Diffusion tensor imaging was performed at 9.4T using a spin-echo diffusion tensor imaging sequence with six gradient directions. Hepatic fat fraction obtained by MR spectroscopy was used as hepatic fat content. Fibrosis scores were obtained from histopathology.
RESULTS: The hepatic fat fractions of the two animal groups were below 5.5% and not different (5.3 ± 1.5 vs. 4.6 ± 1.1%; P = 0.115). Fibrosis scores were higher in CCl4 -treated mice (0.0 ± 0.0 vs. 2.1 ± 0.7; P < 0.001). Nonetheless, there was no difference in ADC between the two groups (0.711 ± 0.068 × 10(-3) vs. 0.718 ± 0.095 × 10(-3) mm(2) s(-1) ; P = 0.911). The treated group had a lower FA than control (0.552 ± 0.050 vs. 0.586 ± 0.013; P = 0.023). ADC was not correlated with hepatic fat fraction and fibrosis. FA was correlated with hepatic fat fraction (r = 0.418, P = 0.011) and fibrosis (r = -0.411, P = 0.012).
CONCLUSION: FA may be more sensitive to mild-to-moderate liver fibrosis than ADC. In addition to ADC, FA may also be sensitive to hepatic fat content, and therefore need careful interpretation in liver fibrosis with concomitant fatty liver. Magn Reson Med, 2014. © 2014 Wiley Periodicals, Inc.
Yunjung Lee; Hyeonjin Kim
Related Documents :
6739404 - Effect of selenium and vitamin e on the development of immunity to coccidiosis in chick...
18547364 - Effects of enzyme addition on the nutritive value of broiler diets containing hulled or...
20308404 - Soybean, palm kernel, and animal-vegetable oils and vitamin e supplementation effect on...
9568294 - Reducing growth rate of broiler chickens with a low energy diet does not improve cortic...
7589044 - Does lowering of cholesterol levels influence functional properties of large arteries?
17369544 - The effect of low-density diets on broiler breeder development and nutrient digestibili...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-4-14
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  -     ISSN:  1522-2594     ISO Abbreviation:  Magn Reson Med     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-4-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Wiley Periodicals, Inc.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Generating a detailed protein profile of Fasciola hepatica during the chronic stage of infection in ...
Next Document:  Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke...