Document Detail

Assessment on dietary melamine exposure from tainted infant formula.
MedLine Citation:
PMID:  19618685     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To estimate the dietary melamine exposure in Chinese infants and young children from the consumption of melamine adulterated Sanlu infant formula. METHODS: Four age groups of infants and young children (3, 6, 12, and 24 months) were chosen as the assessed subjects and the maximum amount of infant formula consumption was estimated based on the recommended usage level in the package insert of Sanlu infant formula and other brands. Melamine was analyzed in 111 Sanlu infant formula samples collected from the markets in Beijing and Gansu province using the LC-MS-MS with a limit of quantification of 0.05 mg/kg. Four levels of melamine concentration were chosen to estimate the dietary intakes, including the mean, median, 90th percentile, and maximum. RESULTS: The infants of 3 months had the highest intake of melamine, and with the increase of the age (month), the intake decreased. Based on the median melamine concentration (1,000 mg/kg) as an example, the melamine intakes for the infants of 3, 6, 12, and 24 months were 23.4, 21.4, 15.0, and 8.6 mg/kg bw/d, respectively. CONCLUSION: Dietary melamine intakes from tainted Sanlu infant formula significantly exceeded the TDI level (0.2 mg/kg bw/d) recommended by the WHO Expert Meeting in 2008. However, the present assessment has some limitations including the poor representative samples, the varied melamine concentrations in the adulterated Sanlu infant formula, and other brand infant formula possibly consumed by these infants.
Xu-Dong Jia; Ning Li; Zhu-Tian Wang; Yun-Feng Zhao; Yong-Ning Wu; Wei-Xing Yan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomedical and environmental sciences : BES     Volume:  22     ISSN:  0895-3988     ISO Abbreviation:  Biomed. Environ. Sci.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-07-21     Completed Date:  2009-08-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8909524     Medline TA:  Biomed Environ Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  100-3     Citation Subset:  IM    
Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
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MeSH Terms
Flame Retardants / analysis,  metabolism
Food Contamination*
Infant Formula / chemistry*
Triazines / chemistry*,  metabolism*
Reg. No./Substance:
0/Flame Retardants; 0/Triazines; 108-78-1/melamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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