Document Detail


Assessment of dementia in patients with multiple system atrophy.
MedLine Citation:
PMID:  19236466     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: We investigated dementia in patients with multiple system atrophy (MSA) in order to characterize the prevalence and nature of impairments in these patients. METHODS: Fifty-eight MSA patients were recruited in our institution between April 1996 and December 2006 and investigated. RESULTS: Of 58 patients, 10 were diagnosed with dementia. There were no significant differences in age at onset, gender, duration of disease, or severity of cerebellar dysfunction between patients with and without dementia. The early and delayed heart to mediastinum (H/M) ratios obtained with (123)I-metaidobenylguanidine (MIBG) cardiac scintigraphy were significantly decreased in patients with dementia compared with those without dementia. Of the 10 patients with dementia, three were found to have cognitive decline that preceded onset of motor symptoms. White matter lesions were evident in these patients, whilst frontal atrophy was prominent in patients whose cognitive decline was preceded by onset of motor symptoms. CONCLUSIONS: Dementia in patients with MSA may be more common than previously thought, furthermore, we speculate that clinical features of dementia in these patients might be heterogeneous.
Authors:
M Kitayama; K Wada-Isoe; Y Irizawa; K Nakashima
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-19
Journal Detail:
Title:  European journal of neurology : the official journal of the European Federation of Neurological Societies     Volume:  16     ISSN:  1468-1331     ISO Abbreviation:  Eur. J. Neurol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-27     Completed Date:  2009-06-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506311     Medline TA:  Eur J Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  589-94     Citation Subset:  IM    
Affiliation:
Department of Neurology, Faculty of Medicine, Institute of Neurological Sciences, Tottori University, Yonago, Japan. mickita@med.tottori-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Dementia / complications*,  pathology,  physiopathology
Female
Heart / radionuclide imaging
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Multiple System Atrophy / epidemiology*,  pathology,  physiopathology
Myocardial Perfusion Imaging
Neuropsychological Tests
Comments/Corrections
Comment In:
Eur J Neurol. 2009 May;16(5):551-2   [PMID:  19405189 ]

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