| Assessment of damage to cerebral white matter fiber in the subacute phase after carbon monoxide poisoning using fractional anisotropy in diffusion tensor imaging. | |
| | |
MedLine Citation:
|
PMID: 20066405 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
INTRODUCTION: Chronic neuropsychiatric symptoms after carbon monoxide (CO) poisoning are caused by demyelination of cerebral white matter fibers. We examined whether diffusion tensor imaging can sensitively represent damage to fibers of the centrum semiovale in the subacute phase after CO intoxication. METHODS: Subjects comprised 13 adult patients with CO poisoning, classified into three groups according to clinical behaviors: group A, patients with transit acute symptoms only; group P, patients with persistent neurological symptoms; and group D, patients with "delayed neuropsychiatric sequelae" occurring after a lucid interval. Median fractional anisotropy (FA) and apparent diffusion coefficient (ADC) of the centrum semiovale bilaterally at 2 weeks were compared between these groups and a control group of ten healthy volunteers. Myelin basic protein (MBP) concentration in cerebrospinal fluid was examined at 2 weeks to evaluate the degree of demyelination in patients. RESULTS: MBP concentration was abnormal or detectable for all group P and group D patients but was undetectable for all patients assigned to group A. Low FA values in groups P and D displaying chronic neurological symptoms clearly differed from those in controls and group A without chronic neurological symptoms, but ADC showed no significant differences between patient groups. CONCLUSIONS: MBP concentration at 2 weeks after CO inhalation confirmed a certain extent of demyelination in the central nervous system of patients who would develop chronic neurological symptoms. In these patients, FA sensitively represented damage to white matter fibers in the centrum semiovale in the subacute phase after CO intoxication. |
| | |
Authors:
|
Takaaki Beppu; Hideaki Nishimoto; Daiya Ishigaki; Shunrou Fujiwara; Tomoyuki Yoshida; Hirotaka Oikawa; Katsura Kamada; Makoto Sasaki; Kuniaki Ogasawara |
Related Documents
:
|
12225315 - Chronic symptoms are common in patients with neuroborreliosis -- a questionnaire follow... 6425855 - Discovery and epidemiology of pcb poisoning in taiwan. 7256525 - Neurological response to hyperbaric oxygen--a criterion for cerebral revascularization. 2299975 - Rocky mountain spotted fever. a clinical review based on 48 confirmed cases, 1943-1986. 932755 - Positional cerebral ischaemia. 1181925 - Changing concepts of duodenitis. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-12 |
Journal Detail:
|
Title: Neuroradiology Volume: 52 ISSN: 1432-1920 ISO Abbreviation: Neuroradiology Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-07-12 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 1302751 Medline TA: Neuroradiology Country: Germany |
Other Details:
|
Languages: eng Pagination: 735-43 Citation Subset: IM |
Affiliation:
|
Departments of Neurosurgery, Iwate Medical University, Uchimaru 19-1, Morioka, 020-8505, Japan. tbeppu@iwate-med.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Anisotropy Brain Damage, Chronic / diagnosis, pathology Carbon Monoxide Poisoning / diagnosis*, pathology Cerebral Cortex / pathology* Chronic Disease Cognition Disorders / diagnosis*, pathology Dementia / diagnosis*, pathology Demyelinating Diseases / diagnosis*, pathology Diffusion Magnetic Resonance Imaging / methods* Dominance, Cerebral / physiology Female Follow-Up Studies Humans Image Processing, Computer-Assisted / methods* Imaging, Three-Dimensional / methods* Magnetic Resonance Imaging / methods* Male Middle Aged Nerve Fibers, Myelinated / pathology* Neurologic Examination Neuropsychological Tests Reference Values Whole Body Imaging* Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Simulating simultanagnosia: spatially constricted vision mimics local capture and the global process...
Next Document: Navigated abdominal T1-W MRI permits free-breathing image acquisition with less motion artifact.