Document Detail

Assessment of damage in Korean patients with systemic lupus erythematosus.
MedLine Citation:
PMID:  17361986     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the prevalence of systemic damage in Korean patients with systemic lupus erythematosus (SLE) and to elucidate associations between possible risk factors and the presence of damage. METHODS: The Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) was used to quantify systemic damage in 588 patients who were enrolled consecutively at the Hospital for Rheumatic Diseases, Seoul, South Korea. The frequencies and means of each variable were compared using the chi-square test or Student t test between the presence and absence of damage. Multivariate models were used to investigate the relationship between possible risk factors (age, disease duration, and use of intravenous cyclophosphamide) and the presence of damage. RESULTS: Among the 588 patients, 244 (41.5%) exhibited damage at a mean of 54 months after onset of disease. The musculoskeletal (14.3% of patients) and renal (13.3%) systems were involved most frequently, followed by neuropsychiatric (10.7%), ocular (4.6%), and pulmonary (4.1%) system involvement. The presence of damage was associated with higher age, longer disease duration, and a high frequency of intravenous cyclophosphamide use. CONCLUSION: Systemic damage in at least one of the items of the SDI was present in 41.5% of our Korean patients with SLE, this damage being significantly more prevalent in patients who were older, had longer disease duration, and received more intravenous pulses of cyclophosphamide.
Yoon-Kyoung Sung; Nam Wook Hur; Jina Lee Sinskey; Dawon Park; Sang-Cheol Bae
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-15
Journal Detail:
Title:  The Journal of rheumatology     Volume:  34     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-04     Completed Date:  2007-06-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  987-91     Citation Subset:  IM    
Department of Internal Medicine, Division of Rheumatology, and Hospital for Rheumatic Diseases, Hanyang University, Seoul, Korea.
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MeSH Terms
Asian Continental Ancestry Group
Cyclophosphamide / adverse effects
Immunosuppressive Agents / adverse effects
Korea / epidemiology
Lupus Erythematosus, Systemic* / epidemiology,  pathology,  physiopathology
Risk Factors
Severity of Illness Index*
Reg. No./Substance:
0/Immunosuppressive Agents; 50-18-0/Cyclophosphamide

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