Document Detail


Assessment of cytogenetic aberrations and comet assay in colorectal adenocarcinomas.
MedLine Citation:
PMID:  12908788     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RESULTS: Cytogenetic evaluation of patients and controls revealed 10 abnormal karyotypes in patients with adenocarcinomas located in the rectum, sigmoid and rectosigmoid regions. Four had numerical and six had structural abnormalities.
CONCLUSIONS: Statistical analysis revealed a significant difference compared with controls (P <0.01). The karyotypes and the extent of DNA damage assessed by the comet assay were also significantly correlated with tumor stage (P <0.01) using the Kruskal-Wallis non-parametric test, while no statistical significance was observed in relation to patient age and smoking.
Authors:
Volkan Baltaci; Semra Sardas; Bulent Aytac; Sami Cakar; Ali Esat Karakaya
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Tumori     Volume:  89     ISSN:  0300-8916     ISO Abbreviation:  Tumori     Publication Date:    2003 May-Jun
Date Detail:
Created Date:  2003-08-11     Completed Date:  2003-09-03     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  0111356     Medline TA:  Tumori     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  305-10     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology-Infertility Center, Ankara University School of Medicine, Turkey. vbaltaci@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / genetics*,  pathology
Adult
Aged
Aged, 80 and over
Case-Control Studies
Cell Movement
Chromosome Aberrations*
Chromosomes / genetics
Colorectal Neoplasms / genetics*,  pathology
Comet Assay
DNA Damage
Female
Gene Deletion
Gene Rearrangement
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Male
Middle Aged
Trisomy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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