Document Detail

Assessment of cytogenetic aberrations and comet assay in colorectal adenocarcinomas.
MedLine Citation:
PMID:  12908788     Owner:  NLM     Status:  MEDLINE    
RESULTS: Cytogenetic evaluation of patients and controls revealed 10 abnormal karyotypes in patients with adenocarcinomas located in the rectum, sigmoid and rectosigmoid regions. Four had numerical and six had structural abnormalities.
CONCLUSIONS: Statistical analysis revealed a significant difference compared with controls (P <0.01). The karyotypes and the extent of DNA damage assessed by the comet assay were also significantly correlated with tumor stage (P <0.01) using the Kruskal-Wallis non-parametric test, while no statistical significance was observed in relation to patient age and smoking.
Volkan Baltaci; Semra Sardas; Bulent Aytac; Sami Cakar; Ali Esat Karakaya
Related Documents :
2004308 - Extramedullary blast crisis in a patient with philadelphia chromosome-positive chronic ...
6581858 - Karyotypic evolution in patients with acute myeloid leukemia.
10829048 - Molecular remission after allogeneic or autologous transplantation of hematopoietic ste...
1390238 - Combination therapy with interferon alpha-2b plus low-dose interferon gamma in pretreat...
17379588 - Treatment of patients with acute ulcerative colitis: conventional corticosteroid therap...
17995988 - Evolving pattern of guillain-barre syndrome in a community hospital in israel.
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Tumori     Volume:  89     ISSN:  0300-8916     ISO Abbreviation:  Tumori     Publication Date:    2003 May-Jun
Date Detail:
Created Date:  2003-08-11     Completed Date:  2003-09-03     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  0111356     Medline TA:  Tumori     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  305-10     Citation Subset:  IM    
Department of Obstetrics and Gynecology-Infertility Center, Ankara University School of Medicine, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenocarcinoma / genetics*,  pathology
Aged, 80 and over
Case-Control Studies
Cell Movement
Chromosome Aberrations*
Chromosomes / genetics
Colorectal Neoplasms / genetics*,  pathology
Comet Assay
DNA Damage
Gene Deletion
Gene Rearrangement
In Situ Hybridization, Fluorescence
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Feasibility of intensity-modulated radiation therapy in the treatment of advanced cervical chordoma.
Next Document:  Cisplatin may be a valid alternative approach in ovarian carcinoma with carboplatin hypersensitivity...