Document Detail


Assessment of craniospinal arteriovenous malformations at 3T with highly temporally and highly spatially resolved contrast-enhanced MR angiography.
MedLine Citation:
PMID:  18339725     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Patients with arteriovenous malformation (AVM) are known to have an elevated risk of complications with conventional catheter angiography (CCA) but nonetheless require monitoring of hemodynamics. Thus, we aimed to evaluate both anatomy and hemodynamics in patients with AVM noninvasively by using contrast-enhanced MR angiography (CE-MRA) at 3T and to compare the results with CCA. MATERIALS AND METHODS: Institutional review board approval and informed consent were obtained for this Health Insurance Portability and Accountability Act-compliant study. Twenty control subjects without vascular malformation (6 men, 18-70 years of age) and 10 patients with AVMs (6 men, 20-74 years of age) underwent supra-aortic time-resolved and high-spatial-resolution CE-MRA at 3T. Large-field-of-view coronal acquisitions extending from the root of the aorta to the cranial vertex were obtained for both MRA techniques. Image quality was assessed by 2 specialized radiologists by using a 4-point scale. AVM characteristics and nidus size were evaluated by using both CE-MRA and CCA in all patients. RESULTS: In patients, 96.6% (319/330) of arterial segments on high-spatial-resolution MRA and 87.7% (272/310) of arterial segments on time-resolved MRA were graded excellent/good. MRA showed 100% specificity for detecting feeding arteries and venous drainage (n = 8) and complete obliteration of the AVM in 2 cases (concordance with CCA). Nidus diameters measured by both MRA and CCA resulted in a very strong correlation (r = 0.99) with a mild overestimation by MRA (0.10 cm by using the Bland-Altman plot). CONCLUSION: By combining highly temporally resolved and highly spatially resolved MRA at 3T as complementary studies, one can assess vascular anatomy and hemodynamics noninvasively in patients with AVM.
Authors:
R S Saleh; D G Lohan; J P Villablanca; G Duckwiler; S T Kee; J P Finn
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Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2008-03-13
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  29     ISSN:  1936-959X     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-14     Completed Date:  2008-06-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1024-31     Citation Subset:  IM    
Affiliation:
Division of Diagnostic Cardiovascular Imaging, Department of Radiology, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095-7206, USA. rsaleh@mednet.ucla.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Female
Gadolinium DTPA / therapeutic use*
Humans
Image Enhancement / methods*
Intracranial Arteriovenous Malformations / diagnosis*
Magnetic Resonance Angiography / methods*
Male
Middle Aged
Reproducibility of Results
Sensitivity and Specificity
Vertebral Artery / abnormalities*,  pathology*
Chemical
Reg. No./Substance:
80529-93-7/Gadolinium DTPA

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