Document Detail

Assessment of the correlation between exposure to benzene and urinary excretion of t, t-muconic acid in workers from a petrochemical plant.
MedLine Citation:
PMID:  12397418     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The investigation covered 148 workers from three plants with different levels of benzene exposure. The aim of the study was to assess the correlation between workers' personal exposure and urinary excretion of t, t-muconic acid (TTMA). METHODS: The personal exposure to benzene was measured by the sampling of the workplace air on sorbent tubes with active charcoal followed by elution with carbon disulphide and gas chromatographic determination. The individual internal exposure was assessed by determination of TTMA in urine by a liquid chromatographic method. The urine samples were collected at the beginning (t(0)) and end (t(1)) of the work shift. RESULTS: The individual whole-shift concentrations of benzene in workplace air in the three studied facilities varied from 0.1 to 67.53 mg/m(3). The concentration of TTMA at the beginning of the shift (t(0)) was from 0.02 to 2.53 mg/l and at the end of the shift (t(1)) was from 0.02 to 9.96 mg/l. Significant correlation was found between benzene level in workplace air and TTMA concentration in urine at the end of the work shift, with a correlation coefficient r=0.425 ( P=0.01). CONCLUSIONS: The analysis of the obtained results shows that TTMA can be used as a biological indicator for benzene exposure. The registered single cases of workers with unexpectedly high results for t, t-muconic acid are explained by their consumption of canned foods containing sorbic acid as a preservative. The subjects involved in similar studies should be advised not to consume canned foods 12 h before the examination.
Teodor Panev; Todor Popov; Tzveta Georgieva; Diana Chohadjieva
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2002-09-10
Journal Detail:
Title:  International archives of occupational and environmental health     Volume:  75 Suppl     ISSN:  0340-0131     ISO Abbreviation:  Int Arch Occup Environ Health     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-24     Completed Date:  2003-04-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7512134     Medline TA:  Int Arch Occup Environ Health     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  S97-100     Citation Subset:  IM    
Department of Toxicology, National Center of Hygiene, 15 D Nestorov Boulevard, 1431 Sofia, Bulgaria.
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MeSH Terms
Benzene / adverse effects*
Biological Markers / analysis
Carcinogens / adverse effects*
Chromatography, Gas
Chromatography, Liquid
Environmental Monitoring / methods
Occupational Exposure*
Sorbic Acid / analogs & derivatives*,  analysis*,  pharmacokinetics
Reg. No./Substance:
0/Biological Markers; 0/Carcinogens; 110-44-1/Sorbic Acid; 505-70-4/muconic acid; 71-43-2/Benzene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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