Document Detail


Assessment of coronary vasodilatation in response to nitroglycerin with transthoracic Doppler echocardiography.
MedLine Citation:
PMID:  16762756     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Previous studies demonstrated impaired coronary vasodilatory response (VR) to nitroglycerin (NG) in patients with coronary atherosclerosis. We hypothesized that the effect of the NG on the coronary blood flow (CBF) is negligible compared with its effect on the epicardial coronary artery dilatation and, therefore, that CBF velocity reduction after NG can reflect the magnitude of epicardial coronary artery dilatation. METHODS: Quantitative coronary angiography was performed at the left anterior descending coronary artery (LAD) before and after intracoronary NG (200 mug) infusion in 18 patients with normal-looking coronary angiogram. VR assessed by quantitative coronary angiography (VRangio) was defined as: (LAD diameter after NG)(2)/(LAD diameter before NG)(2). Mean values measured at the ostium and at the junction of mid and distal LAD were used in the analysis. Diastolic CBF velocity was evaluated by using a 7-MHz transducer at the distal LAD before and 3 minutes after sublingual NG. VR assessed by echocardiography (VRecho) was defined as: (mean diastolic CBF velocity before sublingual NG)/(mean diastolic CBF velocity after sublingual NG). In 11 patients, plaque burden was assessed by intravascular ultrasound and results were compared with VRangio and VRecho. RESULTS: VRecho was found to correlate well with VRangio (r = 0.71, P = .001), and VRangio and VRecho showed significant negative correlations with plaque burden (r = -0.66, P = .03; r = -0.77, P = .005, respectively). CONCLUSIONS: VR to NG can be evaluated noninvasively with transthoracic Doppler echocardiography.
Authors:
Dae-Won Sohn; Yong-Jin Kim; Hyung-Kwan Kim; Kyung-Yi Kim; Bon-Kwon Koo; Joo-Hee Zo; Hyo-Soo Kim; Byung-Hee Oh; Young-Bae Park; Yun-Shik Choi
Related Documents :
17555936 - Transmitral flow patterns and the presence of chronic kidney disease provide independen...
9812096 - Use of intraventricular dispersion of the peak diastolic flow velocity as a marker of l...
7930206 - Influence of acutely altered loading conditions on left atrial appendage flow velocities.
22293446 - Coronary slow flow.
1889056 - Myocardial infarction during pregnancy: a case report.
17072256 - Failure of locoregional anesthesia in dental practice. review of the literature.
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  19     ISSN:  1097-6795     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-09     Completed Date:  2006-08-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  777-80     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, Chongno-Gu, Seoul, Korea. dwsohn@snu.ac.kr
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Blood Flow Velocity / drug effects
Coronary Artery Disease / ultrasonography*
Coronary Circulation / drug effects*
Coronary Vessels / drug effects,  ultrasonography
Echocardiography / methods*
Echocardiography, Doppler / methods
Female
Humans
Image Enhancement / methods*
Infusions, Intra-Arterial
Male
Nitroglycerin / administration & dosage*,  diagnostic use*
Reproducibility of Results
Sensitivity and Specificity
Vasodilation / drug effects*
Chemical
Reg. No./Substance:
55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Exertional changes in circulating cardiac natriuretic peptides in patients with suggested coronary a...
Next Document:  Impact of the coronary flow reduction at rest on myocardial perfusion and functional indices derived...