Document Detail

Assessment of coronary vasodilatation in response to nitroglycerin with transthoracic Doppler echocardiography.
MedLine Citation:
PMID:  16762756     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Previous studies demonstrated impaired coronary vasodilatory response (VR) to nitroglycerin (NG) in patients with coronary atherosclerosis. We hypothesized that the effect of the NG on the coronary blood flow (CBF) is negligible compared with its effect on the epicardial coronary artery dilatation and, therefore, that CBF velocity reduction after NG can reflect the magnitude of epicardial coronary artery dilatation. METHODS: Quantitative coronary angiography was performed at the left anterior descending coronary artery (LAD) before and after intracoronary NG (200 mug) infusion in 18 patients with normal-looking coronary angiogram. VR assessed by quantitative coronary angiography (VRangio) was defined as: (LAD diameter after NG)(2)/(LAD diameter before NG)(2). Mean values measured at the ostium and at the junction of mid and distal LAD were used in the analysis. Diastolic CBF velocity was evaluated by using a 7-MHz transducer at the distal LAD before and 3 minutes after sublingual NG. VR assessed by echocardiography (VRecho) was defined as: (mean diastolic CBF velocity before sublingual NG)/(mean diastolic CBF velocity after sublingual NG). In 11 patients, plaque burden was assessed by intravascular ultrasound and results were compared with VRangio and VRecho. RESULTS: VRecho was found to correlate well with VRangio (r = 0.71, P = .001), and VRangio and VRecho showed significant negative correlations with plaque burden (r = -0.66, P = .03; r = -0.77, P = .005, respectively). CONCLUSIONS: VR to NG can be evaluated noninvasively with transthoracic Doppler echocardiography.
Dae-Won Sohn; Yong-Jin Kim; Hyung-Kwan Kim; Kyung-Yi Kim; Bon-Kwon Koo; Joo-Hee Zo; Hyo-Soo Kim; Byung-Hee Oh; Young-Bae Park; Yun-Shik Choi
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  19     ISSN:  1097-6795     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-09     Completed Date:  2006-08-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  777-80     Citation Subset:  IM    
Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, Chongno-Gu, Seoul, Korea.
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MeSH Terms
Blood Flow Velocity / drug effects
Coronary Artery Disease / ultrasonography*
Coronary Circulation / drug effects*
Coronary Vessels / drug effects,  ultrasonography
Echocardiography / methods*
Echocardiography, Doppler / methods
Image Enhancement / methods*
Infusions, Intra-Arterial
Nitroglycerin / administration & dosage*,  diagnostic use*
Reproducibility of Results
Sensitivity and Specificity
Vasodilation / drug effects*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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