| Assessment of coronary plaque collagen with polarization sensitive optical coherence tomography (PS-OCT). | |
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MedLine Citation:
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PMID: 16434114 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Current evidence indicates that most plaques classified as vulnerable or ruptured plaque do not lead to unstable angina or myocardial infarction. Improved methods are needed to risk stratify plaques to identify those which lead to most acute coronary syndromes. Collagen depletion in the intima overlying lipid collections appears to be a critical component of unstable plaques. In this study, we use polarization sensitive optical coherence tomography (PS-OCT) for the assessment of coronary plaque collagen. Collagen is birefringent, meaning that different polarization states travel through it at different velocities. METHODS AND RESULTS: Changes in PS-OCT images are a measure of tissue birefringence. Twenty-two coronary artery segments were imaged with PS-OCT and analyzed by picrosirius staining (a measure of collagen intensity and fiber size) and trichrome blue. The regression plot between PS-OCT changes and measured collagen yielded a correlation coefficient value of 0.475 (p<0.002). The predictive value of a PS-OCT measurement of negligible birefringence (less than 33% change) for minimal collagen was 93% while the predictive value of high birefringence (greater than 66% change) for high collagen concentrations was 89%. The effect of fiber type (chemical composition) was minimal relative to the effect due to fiber concentration. CONCLUSION: The capability of PS-OCT to assess plaque collagen content, in addition to its ability to generate high resolution structural assessments, make it a potentially powerful technology for identifying high risk plaques. |
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Authors:
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Susanne D Giattina; Brian K Courtney; Paul R Herz; Michelle Harman; Sonya Shortkroff; Debra L Stamper; Bin Liu; James G Fujimoto; Mark E Brezinski |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural Date: 2006-01-23 |
Journal Detail:
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Title: International journal of cardiology Volume: 107 ISSN: 0167-5273 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-02-28 Completed Date: 2006-07-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Ireland |
Other Details:
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Languages: eng Pagination: 400-9 Citation Subset: IM |
Affiliation:
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Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Birefringence Cadaver Collagen / analysis* Coronary Disease / pathology* Female Humans Male Middle Aged Predictive Value of Tests Tomography, Optical Coherence / methods* Tunica Intima / pathology* |
| Grant Support | |
ID/Acronym/Agency:
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1-R01-HL55686/HL/NHLBI NIH HHS; 1-R29-HL55686/HL/NHLBI NIH HHS; 9-R01-EY11289/EY/NEI NIH HHS; R01 AR46996/AR/NIAMS NIH HHS; R01 EB000419/EB/NIBIB NIH HHS; R01-AR44812/AR/NIAMS NIH HHS; R01-HL63953/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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