| Assessment of coronary flow reserve by coronary pressure measurement: comparison with flow- or velocity-derived coronary flow reserve. | |
| | |
MedLine Citation:
|
PMID: 12742297 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: This study sought to assess the reliability of pressure-derived coronary flow reserve (CFR) compared with flow- or velocity-derived CFR. BACKGROUND: Coronary flow reserve has been reported to have important clinical implications for the evaluation and treatment of coronary artery disease. METHODS: Using a pressure guide wire, coronary pressure distal to the stenosis was measured at rest and during hyperemia in seven dogs with various degrees of stenosis and in 30 patients with angina (29 and 34 stenoses in total, respectively). Pressure at the tip of the guiding catheter was also recorded with a fluid-filled transducer system. Pressure-derived CFR was calculated by the square root of the pressure gradient across the stenosis (DeltaP) during hyperemia divided by DeltaP at rest, using a proprietary software system. At the same time, coronary flow was monitored proximal to the stenosis with a flow meter in the experimental dogs, and coronary flow velocity distal to the stenosis was assessed using a Doppler guide wire in patients with angina. Flow-derived (or velocity-derived) CFR was compared with pressure-derived CFR. RESULTS: Except for one stenosis that showed no DeltaP at rest, a significant correlation was obtained between pressure- and flow-derived CFR in the animal study (y = 1.05x - 0.03, r = 0.92, p = 0.0001). A significant correlation was also seen between pressure- and velocity-derived CFR in the human study, except in three stenoses with no resting DeltaP (y = 0.70x + 0.37, r = 0.85, p = 0.0001). CONCLUSIONS: Similar to flow (or velocity) measurement, CFR can be assessed by pressure measurement, except in stenoses with minor resting DeltaP. |
| | |
Authors:
|
Takashi Akasaka; Atsushi Yamamuro; Norio Kamiyama; Yuji Koyama; Maki Akiyama; Nozomi Watanabe; Yoji Neishi; Tsutomu Takagi; Evgeny Shalman; Chen Barak; Kiyoshi Yoshida |
Related Documents
:
|
2091607 - Pain and myocardial ischemia: the role of sympathetic activation. 1838247 - The effect of decreased left-ventricular afterload on cardiac performance in the normal... 1860227 - Instantaneous hyperemic flow-versus-pressure slope index. microsphere validation of an ... 2395367 - Transfemoral balloon aortic occlusion during open cardiopulmonary resuscitation improve... 16398387 - The theoretical basis for using apnoeic oxygenation via the non-ventilated lung during ... 1031947 - Effects of morphine and halothane on canine cardiac function before and after cardiopul... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Validation Studies |
Journal Detail:
|
Title: Journal of the American College of Cardiology Volume: 41 ISSN: 0735-1097 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 2003 May |
Date Detail:
|
Created Date: 2003-05-13 Completed Date: 2003-05-30 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: United States |
Other Details:
|
Languages: eng Pagination: 1554-60 Citation Subset: AIM; IM |
Affiliation:
|
Department of Cardiology, Kawasaki Medical School, Kurashiki City, Okayama, Japan. akasaka@med.kawasaki-m.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Animals Blood Flow Velocity / physiology* Blood Pressure / physiology* Cardiac Volume / physiology* Coronary Angiography Coronary Circulation / physiology* Coronary Stenosis / physiopathology*, radiography Disease Models, Animal Dogs Electrocardiography Female Heart Catheterization Hemorheology Humans Male Middle Aged Reproducibility of Results |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The metabolic syndrome, diabetes, and subclinical atherosclerosis assessed by coronary calcium.
Next Document: Toward clinical risk assessment in hypertrophic cardiomyopathy with gadolinium cardiovascular magnet...