| Assessment of coronary artery stenosis during PTCA by measurement of the trans-stenotic pressure gradient. Comparison with quantitative coronary angiography. | |
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MedLine Citation:
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PMID: 8746905 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A fibreoptic pressure sensor mounted on an 0.018 inch guidewire (Pressure Guide, RadiMedical Systems, Uppsala, Sweden) was used to measure the trans-stenotic pressure gradient in 20 patients admitted for percutaneous transluminal coronary angioplasty (PTCA) of a single, discrete stenosis. Pressure measurements were made both at rest and during maximal vasodilatation induced by intracoronary injection of papaverine. From the ratio of distal coronary pressure divided by the proximal pressure, the relative coronary flow reserve was calculated. The aim of the study was to compare the different pressure-derived parameters by correlating them to stenosis geometry estimated by quantitative coronary angiography. There was a moderate correlation between baseline pressure gradient and percent area stenosis; r = 0.64, P < 0.001 and minimal cross-sectional area; r = 0.45, P < 0.005. A higher correlation was found between hyperaemic pressure gradient and area stenosis (r = 0.80, P < 0.001) and minimal cross-sectional areas, respectively (r = 0.55, P < 0.005). The best correlation was found between relative coronary flow reserve and area stenosis (r = 0.86, P < 0.001) and minimal cross-sectional area (r = 0.70, P < 0.001). In conclusion, pressure measurement using a pressure guidewire is useful as a complement to angiography in evaluation of coronary stenoses during PTCA. Pressures should be measured during maximal vasodilatation. Relative coronary flow reserve calculated from the pressure measurements provides additional information about the fraction of normal maximal flow possible in the presence of a stenosis. |
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Authors:
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C Lamm; P Albertsson; M Dohnal; U Tylén; H Emanuelsson |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: European heart journal Volume: 16 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 1995 Oct |
Date Detail:
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Created Date: 1996-09-26 Completed Date: 1996-09-26 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1367-74 Citation Subset: IM |
Affiliation:
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Department of Radiology, Sahlgrenska University Hospital, Göteborg, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty, Transluminal, Percutaneous Coronary / instrumentation* Blood Pressure / drug effects, physiology* Coronary Angiography* Coronary Circulation / drug effects, physiology* Coronary Disease / diagnosis, physiopathology, therapy* Female Fiber Optic Technology / instrumentation* Humans Hyperemia / physiopathology Male Middle Aged Papaverine / administration & dosage Signal Processing, Computer-Assisted Treatment Outcome Vasodilator Agents / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 58-74-2/Papaverine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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