Document Detail


Assessment of contractile and noncontractile components in human skeletal muscle by magnetic resonance imaging.
MedLine Citation:
PMID:  11870694     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A magnetic resonance imaging (MRI) technique for the assessment of contractile and noncontractile components of human skeletal muscle is described, and the inter-rater and intra-rater test-retest reliability for repeated measurements from the same MR image are examined. Twenty cross-sectional MR images from the right lower leg were obtained from 30 healthy young men and women (mean age 24.1 years, SD 3.3). The anatomical cross-sectional area (aCSA; cm2), the cross-sectional area of noncontractile components (Noncon; cm2), the contractile cross-sectional area (cCSA = aCSA minus Noncon; cm2), and the relative amount of Noncon (%), of the ankle dorsiflexor muscle compartment were determined for each slice using a computer-based image analysis system. Reliability for repeated measurements of the slice with the largest aCSA for the 30 subjects was analyzed by two raters on two different occasions. Inter-rater reliability on both occasions, assessed by the intraclass correlation coefficient (ICC), was excellent for cCSA (ICC3.1 = 0.99) and Noncon (ICC(3.1) > 0.82). Intra-rater (between occasions) reliability was excellent for the two raters for measurements of cCSA (ICC1.1 = 0.99) and Noncon (ICC1.1 > 0.94). Bland and Altman analyses did not identify any clinically relevant bias in the measurements. Method errors were acceptable: within subjects coefficients of variation (CV) was less than 1.8% for cCSA and less than 16.3% for Noncon. It is concluded that repeated measurements of contractile and noncontractile components of the ankle dorsiflexor muscle compartment, obtained from the same MR image, are highly reliable.
Authors:
Anna Maria Holmbäck; Krister Askaner; Stig Holtås; David Downham; Jan Lexell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Muscle & nerve     Volume:  25     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-28     Completed Date:  2002-03-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  United States    
Other Details:
Languages:  eng     Pagination:  251-8     Citation Subset:  IM    
Copyright Information:
Copyright 2002 John Wiley & Sons, Inc.
Affiliation:
Department of Physical Therapy, Lund University Hospital, SE-22185 Lund, Sweden. Anna_Maria.Holmback@sjukgum.lu.se
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MeSH Terms
Descriptor/Qualifier:
Adult
Ankle
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging*
Male
Muscle, Skeletal / anatomy & histology*,  physiology*
Observer Variation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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