Document Detail


Assessment of complement deficiency in patients with meningococcal disease in The Netherlands.
MedLine Citation:
PMID:  10028078     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The frequency of complement deficiency in 176 of 7,732 patients with meningococcal disease in the Netherlands from 1959 through 1992 was assessed. Complement deficiency was found in six patients (3%): 3 (7%) of the patients with Neisseria meningitidis serogroup C disease, 1 (2%) of the patients with N. meningitidis serogroup A disease, and 2 (33%) of the patients with infections due to uncommon serogroups and nongroupable strains of N. meningitidis. Of 91 additional patients with meningococcal infections due to uncommon serogroups, 33% also had complement deficiency. Thirty-four of the 36 complement-deficient patients with meningococcal disease who were from 33 families were 5 years of age or older. Twenty-six additional complement-deficient relatives were found. Screening individuals with meningococcal disease due to uncommon serogroups who were 5 years of age or older identified 30 of the 33 complement-deficient families. Only 27% of the complement-deficient relatives had had meningococcal disease. This risk was lower for relatives with properdin deficiency (18%) than for those deficient in the late component of complement (38%). Therefore, pedigree studies are warranted for identifying those complement-deficient persons who require vaccination for meningococcal disease.
Authors:
C A Fijen; E J Kuijper; M T te Bulte; M R Daha; J Dankert
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  28     ISSN:  1058-4838     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-06-25     Completed Date:  1999-06-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  98-105     Citation Subset:  IM    
Affiliation:
Department of Medical Microbiology, Netherlands Reference Laboratory, University of Amsterdam and RIVM, The Netherlands. c.a.fijen@amc.uva.nl
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Distribution
Cerebrospinal Fluid / microbiology
Child
Child, Preschool
Complement System Proteins / deficiency*
Humans
Infant, Newborn
Meningococcal Infections / epidemiology,  genetics,  immunology*,  mortality
Middle Aged
Neisseria meningitidis / classification,  genetics,  immunology*
Netherlands / epidemiology
Pedigree
Properdin / deficiency*
Recurrence
Chemical
Reg. No./Substance:
11016-39-0/Properdin; 9007-36-7/Complement System Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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