| Assessment of complement deficiency in patients with meningococcal disease in The Netherlands. | |
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MedLine Citation:
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PMID: 10028078 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The frequency of complement deficiency in 176 of 7,732 patients with meningococcal disease in the Netherlands from 1959 through 1992 was assessed. Complement deficiency was found in six patients (3%): 3 (7%) of the patients with Neisseria meningitidis serogroup C disease, 1 (2%) of the patients with N. meningitidis serogroup A disease, and 2 (33%) of the patients with infections due to uncommon serogroups and nongroupable strains of N. meningitidis. Of 91 additional patients with meningococcal infections due to uncommon serogroups, 33% also had complement deficiency. Thirty-four of the 36 complement-deficient patients with meningococcal disease who were from 33 families were 5 years of age or older. Twenty-six additional complement-deficient relatives were found. Screening individuals with meningococcal disease due to uncommon serogroups who were 5 years of age or older identified 30 of the 33 complement-deficient families. Only 27% of the complement-deficient relatives had had meningococcal disease. This risk was lower for relatives with properdin deficiency (18%) than for those deficient in the late component of complement (38%). Therefore, pedigree studies are warranted for identifying those complement-deficient persons who require vaccination for meningococcal disease. |
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Authors:
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C A Fijen; E J Kuijper; M T te Bulte; M R Daha; J Dankert |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Volume: 28 ISSN: 1058-4838 ISO Abbreviation: Clin. Infect. Dis. Publication Date: 1999 Jan |
Date Detail:
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Created Date: 1999-06-25 Completed Date: 1999-06-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9203213 Medline TA: Clin Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 98-105 Citation Subset: IM |
Affiliation:
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Department of Medical Microbiology, Netherlands Reference Laboratory, University of Amsterdam and RIVM, The Netherlands. c.a.fijen@amc.uva.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Distribution Cerebrospinal Fluid / microbiology Child Child, Preschool Complement System Proteins / deficiency* Humans Infant, Newborn Meningococcal Infections / epidemiology, genetics, immunology*, mortality Middle Aged Neisseria meningitidis / classification, genetics, immunology* Netherlands / epidemiology Pedigree Properdin / deficiency* Recurrence |
| Chemical | |
Reg. No./Substance:
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11016-39-0/Properdin; 9007-36-7/Complement System Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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