Document Detail

Assessment of complement deficiency in patients with meningococcal disease in The Netherlands.
MedLine Citation:
PMID:  10028078     Owner:  NLM     Status:  MEDLINE    
The frequency of complement deficiency in 176 of 7,732 patients with meningococcal disease in the Netherlands from 1959 through 1992 was assessed. Complement deficiency was found in six patients (3%): 3 (7%) of the patients with Neisseria meningitidis serogroup C disease, 1 (2%) of the patients with N. meningitidis serogroup A disease, and 2 (33%) of the patients with infections due to uncommon serogroups and nongroupable strains of N. meningitidis. Of 91 additional patients with meningococcal infections due to uncommon serogroups, 33% also had complement deficiency. Thirty-four of the 36 complement-deficient patients with meningococcal disease who were from 33 families were 5 years of age or older. Twenty-six additional complement-deficient relatives were found. Screening individuals with meningococcal disease due to uncommon serogroups who were 5 years of age or older identified 30 of the 33 complement-deficient families. Only 27% of the complement-deficient relatives had had meningococcal disease. This risk was lower for relatives with properdin deficiency (18%) than for those deficient in the late component of complement (38%). Therefore, pedigree studies are warranted for identifying those complement-deficient persons who require vaccination for meningococcal disease.
C A Fijen; E J Kuijper; M T te Bulte; M R Daha; J Dankert
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  28     ISSN:  1058-4838     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-06-25     Completed Date:  1999-06-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  98-105     Citation Subset:  IM    
Department of Medical Microbiology, Netherlands Reference Laboratory, University of Amsterdam and RIVM, The Netherlands.
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MeSH Terms
Age Distribution
Cerebrospinal Fluid / microbiology
Child, Preschool
Complement System Proteins / deficiency*
Infant, Newborn
Meningococcal Infections / epidemiology,  genetics,  immunology*,  mortality
Middle Aged
Neisseria meningitidis / classification,  genetics,  immunology*
Netherlands / epidemiology
Properdin / deficiency*
Reg. No./Substance:
11016-39-0/Properdin; 9007-36-7/Complement System Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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