Document Detail

Assessment of colorectal hepatic metastases by quantitative T2 relaxation time.
MedLine Citation:
PMID:  21724358     Owner:  NLM     Status:  MEDLINE    
AIM: To determine the T(2) relaxation time of colorectal hepatic metastases and changes in T(2) relaxation times following chemotherapy.
MATERIALS AND METHODS: 42 patients with 96 hepatic colorectal metastases underwent baseline MRI. Axial T(1), T(2) and multi-echo GRASE sequences were acquired. ROIs were drawn on T(2) relaxation maps, obtained from GRASE images, encompassing metastasis and normal liver to record T(2) relaxation time values. In 11 patients with 28 metastases, MRI was repeated using same protocol at 6 weeks following chemotherapy. The median pre-treatment T(2) values of metastases and normal liver were compared using the Mann-Whitney test. The pre- and post-treatment median T(2) values of metastases were compared using the Wilcoxon-Rank test for responding (n=16) and non-responding (n=12) lesions defined by RECIST criteria. The change in T(2) values (ΔT(2)) were compared and correlated with percentage change in lesion size.
RESULTS: There was no difference in the pre-treatment median T(2) of metastases between responding (67.3±8.6) and non-responding metastases (71.4±16.5). At the end of chemotherapy, there was a decrease in the median T(2) of responding lesions (61.6±12.6) p=0.83, and increase in non-responding lesions (76.2±18.4) p=0.03, but these were not significantly different from the pre-treatment values. There was no significant difference in ΔT(2) of responding and non-responding lesions (p=0.18) and no correlation was seen between size change and ΔT(2) (coefficient=0.3).
CONCLUSION: T(2) relaxation time does not appear to predict response of colorectal liver metastasis to chemotherapy.
S Arsalan Raza; L Funicelli; S A Sohaib; D J Collins; E Scurr; M O Leach; D-M Koh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-07-02
Journal Detail:
Title:  European journal of radiology     Volume:  81     ISSN:  1872-7727     ISO Abbreviation:  Eur J Radiol     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-14     Completed Date:  2012-07-16     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8106411     Medline TA:  Eur J Radiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  e536-40     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Colorectal Neoplasms / pathology*
Image Enhancement / methods
Image Interpretation, Computer-Assisted / methods*
Liver Neoplasms / pathology*,  secondary*
Magnetic Resonance Imaging / methods*
Middle Aged
Reproducibility of Results
Sensitivity and Specificity
Grant Support
C1060/A808//Cancer Research UK; G0701533//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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