Document Detail


Assessment of collateralized myocardium with Cardiac Magnetic Resonance (CMR): transmural extent of infarction but not angiographic collateral vessel filling determines regional function and perfusion in collateral-dependent myocardium.
MedLine Citation:
PMID:  17101182     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Angiographic collateral vessel filling is limited to evaluate collateral-dependent myocardium. We hypothesize, that quantitative assessment of regional myocardial function, perfusion and viability with Cardiac Magnetic Resonance (CMR) adds complementary information to angiography of collateralized myocardium. METHODS: CMR was performed in 30 patients with one chronic occluded coronary artery and no further flow limiting stenosis to assess transmural extend of infarction (TEI), resting perfusion and perfusion during adenosine-induced hyperemia and regional wall thickening (RWT) in collateral-dependent and antegradely-perfused myocardium. Collateral vessels were evaluated by angiography and the Rentrop grade (0-3). RESULTS: In 15 patients with < 50% TEI in collateral-dependent myocardium resting perfusion (1.08+/-0.22 ml/min/g), hyperemia (2.21+/-0.73 ml/min/g) and RWT (4.0+/-2.6 mm) were similar to antegradely-perfused myocardium (rest 1.14+/-0.20 and hyperemia 2.46+/-0.82 ml/min/g, RWT 4.3+/-1.7 mm). In 15 patients with > or = 50% TEI in collateral-dependent myocardium resting perfusion and hyperemia as well as RWT were significantly lower (rest 0.84+/-0.19, p<0.001 and hyperemia 1.34+/-0.43 ml/min/g, p<0.001; RWT 1.0+/-1.0 mm, p<0.0001) compared to antegradely-perfused myocardium. There was an inverse correlation between TEI and resting or hyperemic perfusion or RWT. In contrary, resting perfusion and hyperemia as well as RWT in collateral-dependent myocardium were not different between patients with good (2-3) compared to patients with poor Rentrop grade (0-1). There was no correlation between TEI and Rentrop grade. CONCLUSION: Function and perfusion in collateral-dependent myocardium are preserved, if transmural extent of infarction is limited (< 50%). This is independent of their angiographic collateral vessel filling. Thus, CMR adds complementary information to angiographic standard assessment of collateral vessels.
Authors:
Olaf Muehling; Michael Jerosch-Herold; Clemens Cyran; Armin Huber; Stefan Schoenberg; Maximilian Reiser; Gerhard Steinbeck; Michael Nabauer
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural     Date:  2006-11-13
Journal Detail:
Title:  International journal of cardiology     Volume:  120     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-09     Completed Date:  2007-09-28     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  38-44     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Munich, Germany. olaf.muehling@med.uni-muenchen.de
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MeSH Terms
Descriptor/Qualifier:
Aged
Collateral Circulation / physiology*
Coronary Angiography
Coronary Circulation / physiology*
Coronary Stenosis / complications,  pathology,  physiopathology*
Female
Humans
Magnetic Resonance Imaging*
Male
Middle Aged
Myocardial Infarction / etiology,  pathology*,  physiopathology*
Stroke Volume / physiology
Ventricular Remodeling
Grant Support
ID/Acronym/Agency:
R01 HL65394-01/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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