Document Detail

Assessment of cognitive functions in severely paralysed and severely brain-damaged patients: neuropsychological and electrophysiological methods.
MedLine Citation:
PMID:  15519949     Owner:  NLM     Status:  MEDLINE    
A systematic neuropsychological assessment technique is described for use with severely physically disabled individuals, possibly with combined motor and cognitive disorders. Target neurological conditions may be, e.g., an incomplete locked-in state, a minimally conscious state, or severe combinations of paralysis, agnosia, and apraxia. Neuropsychological assessment in these patients is difficult, because standard neuropsychological tests require fast motor responses, which can be manual, verbal, or both. To assess the cognitive status of patients with residual motor function, tests have been applied that can be answered by a binary (yes/no) signal and whose outcomes were not based on reaction times. Further, a battery of neurophysiological examination procedures based on event-related brain potentials has been developed. These procedures can be performed directly at a patient's bedside (at home or in a hospital) and applied for assessment of cognitive functions even in patients without residual motor function.
Nicola Neumann; Boris Kotchoubey
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research. Brain research protocols     Volume:  14     ISSN:  1385-299X     ISO Abbreviation:  Brain Res. Brain Res. Protoc.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-02     Completed Date:  2005-02-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9716650     Medline TA:  Brain Res Brain Res Protoc     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  25-36     Citation Subset:  IM    
Institute of Medical Psychology and Behavioral Neurobiology, University of Tuebingen, D-72074 Tuebingen, Germany.
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MeSH Terms
Brain Injuries / diagnosis*,  physiopathology
Clinical Protocols
Consciousness Disorders / diagnosis*,  physiopathology
Evoked Potentials
Neuropsychological Tests* / standards
Quadriplegia / diagnosis*,  physiopathology

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