Document Detail


Assessment of chronic trigeminal neuropathic pain by the orofacial operant test in rats.
MedLine Citation:
PMID:  22743005     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Classical behavioral tests in animal models of trigeminal neuropathic pain measure reflexive responses that are not necessarily measures of pain. To overcome the problem, we created a chronic constrictive nerve injury (CCI) rat model of pain by ligation of the infraorbital nerve (ION), and applied the orofacial operant test to assess behavioral responses to mechanical and cold stimulation in these rats. Animals were trained to voluntarily contact their facial region to a mechanical or a cold stimulation module in order to access sweetened milk as a positive reward. ION-CCI rats displayed aversive behaviors to innocuous mechanical stimuli, as indicated by a significant decrease in both contact time and the numbers of long contact events in comparison with sham group. For cold stimulation, ION-CCI rats displayed aversive behaviors to both innocuous (17 °C) and noxious cold temperatures (12 °C and 5 °C), as indicated by a significant decrease in both contact time and the numbers of long contact events at the cooling temperatures. The decreases of the contact time and numbers in ION-CCI rats were partially abolished by morphine. Our orofacial operant test demonstrates mechanical allodynia, cold allodynia, and hyperalgesia in rats with chronic trigeminal nerve injury. The neuropathic pain in ION-CCI rats was partially alleviated by morphine. Thus, orofacial operant test provides a desirable behavioral assessment method for preclinical studies of chronic trigeminal neuropathic pain.
Authors:
Myeounghoon Cha; Kevin J Kohan; Xiaozhuo Zuo; Jennifer X Ling; Jianguo G Gu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-06-26
Journal Detail:
Title:  Behavioural brain research     Volume:  234     ISSN:  1872-7549     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-07-30     Completed Date:  2012-12-07     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  82-90     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Analgesics, Opioid / therapeutic use
Animals
Behavior, Animal / physiology*
Chronic Pain / drug therapy,  physiopathology*
Cold Temperature
Disease Models, Animal*
Facial Pain / drug therapy,  physiopathology*
Hyperalgesia / physiopathology
Male
Morphine / therapeutic use
Neuralgia / drug therapy,  physiopathology
Pain Measurement
Pain Threshold / physiology
Rats
Rats, Sprague-Dawley
Reward
Trigeminal Nerve Diseases / drug therapy,  physiopathology*
Grant Support
ID/Acronym/Agency:
DE018661/DE/NIDCR NIH HHS; R01 DE018661/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Analgesics, Opioid; 76I7G6D29C/Morphine
Comments/Corrections

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