| Assessment of chronic exposure to cigarette smoke and its change during pregnancy by segmental analysis of maternal hair nicotine. | |
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MedLine Citation:
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PMID: 12679794 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study aimed to investigate the association between biomarkers of fetal exposure to smoking during the whole pregnancy, nicotine in maternal and newborns hair samples, and quantitative measurement of smoking intake and exposure evaluated by maternal self-reported questionnaire. Study subjects were 150 mothers and their newborns from a hospital in Barcelona. A questionnaire including smoking habits was completed in the third trimester of pregnancy and on the day of delivery. Nicotine content was measured in two subsequent segments of maternal hair accounting for the first and last months of pregnancy, and in fetal hair. The geometric mean of nicotine concentration in maternal hair discriminated between nonexposition (3.84 and 2.80 ng/mg in distal and proximal hair segment, respectively) and exposition to cigarette smoke during pregnancy (6.06 and 4.30 ng/mg in distal and proximal hair segment, respectively) (P<0.05), and between these two classes and active smoking (14.40 and 11.08 ng/mg in distal and proximal hair segment, respectively). Maternal hair nicotine was able to differentiate levels of exposure to tobacco smoke and levels of intake. Nicotine concentration in hair from newborns did not differentiate between exposure and nonexposure to environmental tobacco smoke (ETS) in nonsmoking mothers. Finally, chronic exposure to cigarette smoke during pregnancy, assessed by maternal hair nicotine, correlated negatively with anthropometric parameters of newborns. |
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Authors:
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Simona Pichini; Oscar Garcia-Algar; Laura Muñoz; Oriol Vall; Roberta Pacifici; Cecilia Figueroa; José Antonio Pascual; David Diaz; Jordi Sunyer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of exposure analysis and environmental epidemiology Volume: 13 ISSN: 1053-4245 ISO Abbreviation: J Expo Anal Environ Epidemiol Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-04-07 Completed Date: 2003-08-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9111438 Medline TA: J Expo Anal Environ Epidemiol Country: England |
Other Details:
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Languages: eng Pagination: 144-51 Citation Subset: IM |
Affiliation:
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Clinical Biochemistry Dept. Istituto Superiore di Sanità, Roma, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / analysis Environmental Exposure* Female Ganglionic Stimulants / analysis*, pharmacokinetics Hair / chemistry* Humans Maternal-Fetal Exchange Nicotine / analysis*, pharmacokinetics Pregnancy Questionnaires Tobacco Smoke Pollution / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Ganglionic Stimulants; 0/Tobacco Smoke Pollution; 54-11-5/Nicotine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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