| Assessment of cervical antibody concentrations fails to enhance the value of cervical length as a predictor of preterm delivery. | |
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MedLine Citation:
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PMID: 15746687 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to determine if cervical fluid antibody concentrations can enhance the value of cervical length in predicting risk of preterm delivery. STUDY DESIGN: We obtained cervical fluid samples with preweighed cellulose wicks from a prospective cohort of women 23 to 32 weeks' gestation with signs and symptoms of preterm labor and intact membranes. Total immunoglobulin A and G (IgA and IgG) concentrations were determined by enzyme-linked immunosorbent assay. Bacterial vaginosis was diagnosed by Gram stain, and cervical length was measured with endovaginal ultrasound. RESULTS: For subjects with term (n = 77) and preterm (n = 24) deliveries, median IgA and IgG concentrations were 736 vs 643 microg/mL (P = .33) and 1528 vs 1769 microg/mL (P = .85). For subjects with normal flora (n = 71), intermediate flora (n = 14), and bacterial vaginosis (n = 16), median IgA and IgG concentrations were 717, 624, and 774 microg/mL (P = .90) and 1383, 1553, and 2731 microg/mL (P = .02). In a forward stepwise logistic regression model, cervical length was the only factor associated with preterm delivery (P < .001). CONCLUSION: Measuring the concentrations of IgA and IgG in cervical fluid does not enhance the value of cervical length in predicting risk of preterm delivery. |
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Authors:
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Rodney K Edwards; Ronald J Ferguson; Jonathan J Shuster; Douglas Theriaque; Susan Gentry; Patrick Duff |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 192 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-03-04 Completed Date: 2005-04-01 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 887-91 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, Florida, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antibodies / analysis* Body Fluids / immunology Cervix Uteri / anatomy & histology*, immunology*, ultrasonography Enzyme-Linked Immunosorbent Assay Female Humans Immunoglobulin A / analysis Immunoglobulin G / analysis Premature Birth / diagnosis* Prospective Studies Vaginosis, Bacterial / complications, immunology |
| Grant Support | |
ID/Acronym/Agency:
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M01-RR00082/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Immunoglobulin A; 0/Immunoglobulin G |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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