Document Detail

Assessment of carotid intima-media thickness in subjects with ischemic cerebrovascular events undergoing endarterectomy.
MedLine Citation:
PMID:  17126769     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIM: In clinical settings, the degree of lumen stenosis is the parameter used to select patients for carotid surgery. The present study was designed to measure carotid intima-media thickness (IMT), an indicator of atherosclerotic burden, in a sample of consecutive patients with ischemic cerebrovascular events referred for endarterectomy. METHODS AND RESULTS: Carotid endarterectomy specimens from 55 consecutive patients (age 66+/-10 years) admitted to hospital with recent documented atherothrombotic ischemic cerebrovascular events were compared with 24 carotid arteries from people (age 68+/-11 years) who had died from documented causes unrelated to cerebrovascular disease. Measurement of extracranial carotid atherosclerosis was made from three anatomically defined segments, using image-processing software. A total of 426 cross sections was analyzed. Increasing IMT measures were clearly associated with increased risk of an ischemic event. Single maximum IMT values of 2.33 mm (95% CI, 1.69-2.96) for the common carotid, 2.45 mm (95% CI, 1.97-2.93) for the bifurcation, and 2.23 (95% CI, 1.83-2.64) for the internal carotid were associated with a 75% probability of a cerebrovascular ischemic accident. Receiver operator characteristic curve analyses demonstrated that the diagnostic ability of IMT measurements performed at the level of internal carotid artery to separate cases from controls was greater than common carotid artery or bifurcation measurements. CONCLUSIONS: The present pathology study provides data on IMT in patients admitted to hospital for cerebrovascular accidents and referred for carotid endarterectomy.
Mario De Michele; Daniel J Zaccaro; Gene Bond
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Publication Detail:
Type:  Journal Article     Date:  2006-04-27
Journal Detail:
Title:  Nutrition, metabolism, and cardiovascular diseases : NMCD     Volume:  16     ISSN:  1590-3729     ISO Abbreviation:  Nutr Metab Cardiovasc Dis     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-27     Completed Date:  2006-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111474     Medline TA:  Nutr Metab Cardiovasc Dis     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  536-42     Citation Subset:  IM    
Division of Cardiology, Moscati Hospital, Aversa, Italy. <>
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MeSH Terms
Brain Ischemia / pathology*,  surgery
Carotid Arteries / pathology*
Endarterectomy, Carotid*
Middle Aged
ROC Curve
Tunica Intima / pathology*
Tunica Media / pathology*

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