| Assessment of cardiac function in three mouse dystrophinopathies by magnetic resonance imaging. | |
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MedLine Citation:
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PMID: 22209498 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Lack of dystrophin results in skeletal muscle dystrophy and dilated cardiomyopathy in humans and animal models. To achieve a basic understanding of the natural development of cardiomyopathy in different dystrophinopathy mouse models, left and right ventricular heart function was assessed at different ages in three dystrophinopathy mouse models (mdx, mdx/utrn(+/-) model and mdx/utrn(-/-)) using magnetic resonance imaging. Left ventricular function was significantly decreased, already at 2months in the most severely affected mdx/utrn(-/-) mice. Furthermore, whereas heart function was stable in wild-type mice over time, both mdx and mdx/utrn(+/-) showed a clear decrease at 10months of age, most prominently in the right ventricle. Therefore magnetic resonance imaging is an adequate technique to determine heart function in dystrophinopathy mouse models and can be used to assess the effect of potential therapies. |
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Authors:
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Ingrid E C Verhaart; Rianne J M van Duijn; Brigit den Adel; Arno A W Roest; Jan J G M Verschuuren; Annemieke Aartsma-Rus; Louise van der Weerd |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-29 |
Journal Detail:
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Title: Neuromuscular disorders : NMD Volume: - ISSN: 1873-2364 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-1-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9111470 Medline TA: Neuromuscul Disord Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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