| Assessment of cardiac function in patients with heart disease by quantitative gated myocardial perfusion SPECT. | |
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MedLine Citation:
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PMID: 17705010 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We examined the cardiac function of patients who underwent Tc-99m sestamibi quantitative gated myocardial single photon emission computed tomography with 16-framing data acquisition between January 1, 2004 and March 31, 2006 for an evaluation of suspected or known heart disease in our hospital. METHODS: In 192 patients aged >or=40 years, the left ventricular (LV) systolic function [parameter: ejection fraction (EF)] and diastolic function [first third filling fraction (1/3FF), peak filling rate (PFR), and time-to-peak filling (TPF)] were estimated by volume curve analysis. In 51 (age >or=60 years) of 192 patients, brachial-ankle pulse wave velocity (baPWV) was also measured. RESULTS: The correlation between diastolic parameters PFR and 1/3FF was mild (r = 0.28, P < 0.001). On the basis of EF and PFR, 192 patients were divided into four groups: P (preserved LV function), Q (isolated systolic dysfunction, EF < 50%), R (isolated diastolic dysfunction, PFR < 1.8 EDV/s), and S (both dysfunctions). The numbers of patients in P, Q, R, and S groups were 94 (49.0%), 7 (3.6%), 31 (16.1%), and 60 (31.3%), respectively. The 1/3FF correlated weakly but significantly with age (r = -0.16, P < 0.05). The TPF also correlated weakly with age (r = 0.25, P < 0.01), but EF did not. The baPWV, an indicator of cardiovascular stiffness, correlated inversely with 1/3FF (r = -0.59, P < 0.001) or correlated positively with TPF (r = 0.45, P < 0.001), but not with EF. CONCLUSIONS: Our study suggests that cardiovascular stiffness associated with increased baPWV may contribute to the occurrence of diastolic dysfunction in elderly patients. |
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Authors:
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Ichiro Nakae; Shinro Matsuo; Takayoshi Tsutamoto; Tetsuya Matsumoto; Kenichi Mitsunami; Minoru Horie |
Publication Detail:
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Type: Journal Article Date: 2007-08-27 |
Journal Detail:
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Title: Annals of nuclear medicine Volume: 21 ISSN: 0914-7187 ISO Abbreviation: Ann Nucl Med Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-08-20 Completed Date: 2007-12-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8913398 Medline TA: Ann Nucl Med Country: Japan |
Other Details:
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Languages: eng Pagination: 315-23 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Seta, Otsu 520-2192, Japan. nakae@belle.shiga-med.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Female Gated Blood-Pool Imaging / methods* Humans Male Middle Aged Radiopharmaceuticals / diagnostic use Reproducibility of Results Sensitivity and Specificity Technetium Tc 99m Sestamibi / diagnostic use* Tomography, Emission-Computed, Single-Photon / methods* Ventricular Dysfunction, Left / radionuclide imaging* |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 109581-73-9/Technetium Tc 99m Sestamibi |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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