Document Detail

Assessment of cardiac asynchrony by radionuclide phase analysis: correlation with ventricular function in patients with narrow or prolonged QRS interval.
MedLine Citation:
PMID:  17347038     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Conflicting data exist on the relation between the synchronism of cardiac contraction and ventricular function.
AIM AND METHODS: A resting radionuclide ventriculography (RNV) was performed in 380 consecutive patients to evaluate the relationship between the synchronism of cardiac contraction and ventricular function.
RESULTS: A significant, non-linear, relation was found between LVEF and intra-ventricular asynchrony or QRS, but not between inter-ventricular asynchrony and LVEF. A linear correlation was observed between QRS and intra-ventricular or inter-ventricular asynchrony. Intra-ventricular asynchrony was identified as the major, independent, determinant of LV function. With the increase in QRS duration, a decrease in LVEF (p<0.001), and a worsening of either intra-ventricular (p<0.001) or inter-ventricular synchronism (p<0.05), was documented. However, 48% of patients with QRS 120-150 ms had abnormal inter-ventricular and 42% abnormal intra-ventricular synchronism, while 27% of patients with QRS>150 ms had normal inter-ventricular and 25% normal intra-ventricular synchronism.
CONCLUSIONS: Intra-ventricular asynchrony was identified as the major determinant of ventricular dysfunction. A consistent proportion of patients had asynchrony despite preserved QRS duration or normal synchronism with a QRS>150 ms. Fourier phase analysis of RNV may detect asynchrony better than QRS. The role of RNV for detection of individual patients who may most benefit from resynchronization therapy requires additional investigations.
Claudio Marcassa; R Campini; Edoardo Verna; Luca Ceriani; Pantaleo Giannuzzi
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Publication Detail:
Type:  Journal Article     Date:  2007-03-07
Journal Detail:
Title:  European journal of heart failure     Volume:  9     ISSN:  1388-9842     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-17     Completed Date:  2007-09-20     Revised Date:  2011-06-08    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  484-90     Citation Subset:  IM    
Division of Cardiology, Salvatore Maugeri Foundation IRCCS, Scientific Institute of Veruno (NO), Italy.
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MeSH Terms
Analysis of Variance
Artificial Intelligence
Cardiomyopathy, Dilated / physiopathology,  radionuclide imaging
Case-Control Studies
Fourier Analysis
Heart Conduction System / physiopathology*,  radionuclide imaging*
Heart Ventricles / physiopathology,  radionuclide imaging
Middle Aged
Myocardial Contraction
Myocardial Ischemia / physiopathology,  radionuclide imaging
Observer Variation
Radionuclide Ventriculography*
Regression Analysis
Reproducibility of Results
Stroke Volume
Ventricular Function, Left*

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