Document Detail


Assessment of cardiac abnormalities in Duchenne's muscular dystrophy by (99m)Tc-MIBI gated myocardial perfusion imaging.
MedLine Citation:
PMID:  22833857     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Cardiac abnormalities in Duchenne's muscular dystrophy (DMD) are often detected in adult patients and their early detection is warranted. Studies have suggested that myocardial damage may be detected by cardiovascular magnetic resonance imaging or by echocardiography at the early stage of DMD. We aimed to identify early changes of cardiac abnormalities in children with DMD by technetium 99m-methoxyisobutylisonitrile ((99m)Tc-MIBI) gated myocardial perfusion imaging (GMPI). Forty-three boys aged 3 to 14 years (mean age 8.2±3.6 years) with DMD and 12 age-matched normal boys as control were studied by G-MPI. These patients were at early stage according to previous studies on DMD. Uptake of (99m)Tc-MIBI in 7 regional walls and 17 segments of the left ventricle were visually analyzed. Quantitative gated single photon emission tomography (QGSSPET) analysis of myocardium was performed to evaluate left ventricular function (LVEF). Gated myocardial perfusion imaging revealed cardiac abnormalities in 81.4% of all patients. Regional perfusion decrease involving multiple walls of LV was present. Four of the patients demonstrated mild abnormalities (11.4%), 7 moderate (20.0%) and 24 severe abnormalities (68.6%). Evident LV ejection fraction (EF) decrease (42.1±6.4%) and dilation with globally poor perfusion were found in three patients, aged 10 to 14, which had significant difference compared with the control group (EF=58.4±4.7%, P=0.001). The rest cases, aged 3 to 9 years, had normal LVF. In conclusion, from the 35 cases of DMD patients (aged 3 to 14 years), regional myocardial perfusion decrease was detected in multiple walls by (99m)Tc-MIBI G-MPI at an early stage, while left ventricular function decrease (3/35, 8.6%) appeared late at about 10 years of age or older as compared with the control group in this study.
Authors:
Peng Fu; Lingge Hu; Jing Sinzinger; Jianmin Huang; Xiaomei Liu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hellenic journal of nuclear medicine     Volume:  15     ISSN:  1790-5427     ISO Abbreviation:  Hell J Nucl Med     Publication Date:    2012 May-Aug
Date Detail:
Created Date:  2012-07-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101257471     Medline TA:  Hell J Nucl Med     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  114-9     Citation Subset:  IM    
Affiliation:
Department of Nuclear Medicine, 3rd Hospital of Hebei Medical College, Shijiazhuang 050051, Hebei Province, China. weilingge@yeah.net.
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