| Assessment of canine vocal fold function after injection of a new biomaterial designed to treat phonatory mucosal scarring. | |
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MedLine Citation:
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PMID: 21510143 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVES: Most cases of irresolvable hoarseness are due to deficiencies in the pliability and volume of the superficial lamina propria of the phonatory mucosa. By using a US Food and Drug Administration-approved polymer, polyethylene glycol (PEG), we created a novel hydrogel (PEG30) and investigated its effects on multiple vocal fold structural and functional parameters. METHODS: We injected PEG30 unilaterally into 16 normal canine vocal folds with survival times of 1 to 4 months. High-speed videos of vocal fold vibration, induced by intratracheal airflow, and phonation threshold pressures were recorded at 4 time points per subject. Three-dimensional reconstruction analysis of 11.7 T magnetic resonance images and histologic analysis identified 3 cases wherein PEG30 injections were the most superficial, so as to maximally impact vibratory function. These cases were subjected to in-depth analyses. RESULTS: High-speed video analysis of the 3 selected cases showed minimal to no reduction in the maximum vibratory amplitudes of vocal folds injected with PEG30 compared to the non-injected, contralateral vocal fold. All PEG30-injected vocal folds displayed mucosal wave activity with low average phonation threshold pressures. No significant inflammation was observed on microlaryngoscopic examination. Magnetic resonance imaging and histologic analyses revealed time-dependent resorption of the PEG30 hydrogel by phagocytosis with minimal tissue reaction or fibrosis. CONCLUSIONS: The PEG30 hydrogel is a promising biocompatible candidate biomaterial to restore form and function to deficient phonatory mucosa, while not mechanically impeding residual endogenous superficial lamina propria. |
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Authors:
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Sandeep S Karajanagi; Gerardo Lopez-Guerra; Hyoungshin Park; James B Kobler; Marilyn Galindo; Jon Aanestad; Daryush D Mehta; Yoshihiko Kumai; Nicholas Giordano; Anthony d'Almeida; James T Heaton; Robert Langer; Victoria L M Herrera; William Faquin; Robert E Hillman; Steven M Zeitels |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Annals of otology, rhinology, and laryngology Volume: 120 ISSN: 0003-4894 ISO Abbreviation: Ann. Otol. Rhinol. Laryngol. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-04-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0407300 Medline TA: Ann Otol Rhinol Laryngol Country: United States |
Other Details:
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Languages: eng Pagination: 175-84 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital, Boston, MA 02114, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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