Document Detail

Assessment by continuous cardiac monitoring of minimum duration of preoperative propranolol treatment in thyrotoxic patients.
MedLine Citation:
PMID:  1269165     Owner:  NLM     Status:  MEDLINE    
The effect of the beta-blocker, propranolol (40 mg 6-hourly orally) has been studied on the tachycardia of six patients with untreated thyrotoxicosis. Heart rate was monitored continuously using a light portable ECG recorder which allowed the patients to undertake normal activities during the recording periods. The most marked reduction in heart rate was evident at 24 h after starting propranolol treatment. In three of the patients there was only a minor further fall in heart rate despite continued propranolol administration, but in the remaining patients the reduction in heart rate with each successive day of treatment was more marked. These results suggest that if propranolol were to be used alone in the preparation of patients before partial thyroidectomy for thyrotoxicosis, a dose of 40 mg 6-hourly for 3-4 days might be sufficient.
A D Toft; W J Irvine; R W Campbell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical endocrinology     Volume:  5     ISSN:  0300-0664     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  1976 Mar 
Date Detail:
Created Date:  1976-08-02     Completed Date:  1976-08-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  195-8     Citation Subset:  IM    
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MeSH Terms
Heart Rate / drug effects
Hyperthyroidism / complications*
Middle Aged
Preoperative Care
Propranolol / administration & dosage*,  therapeutic use
Tachycardia / drug therapy*,  etiology
Time Factors
Reg. No./Substance:

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