Document Detail


Assessment of brain perfusion with MR imaging.
MedLine Citation:
PMID:  3170829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A technique for assessing brain perfusion with magnetic resonance (MR) imaging is described. This technique uses two spin echo sequences that are identical except that the second is sensitised to blood flow by use of a pair of unipolar gradients on either side of the 180 degree pulse. Differences in phase between the two sequences are displayed with a sensitivity to flow rates of +/- 0.5, +/- 1, and +/- 2 mm/s per full scale (+/- pi radians) deflection. The technique was validated for measurement of flow at these rates with a water phantom. Ten patients with cerebrovascular disease, multiple sclerosis, cerebral tumor, periventricular leukomalacia, and meningitis were studied. Differences between grey and white matter were normally seen in adults. Infants displayed differences between central and peripheral regions of the brain. Abnormalities were seen in all clinical cases. The technique will require further validation but it appears to provide a totally noninvasive method for assessing brain perfusion.
Authors:
I R Young; A S Hall; D J Bryant; D G Thomas; S S Gill; L M Dubowitz; F Cowan; J M Pennock; G M Bydder
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of computer assisted tomography     Volume:  12     ISSN:  0363-8715     ISO Abbreviation:  J Comput Assist Tomogr     Publication Date:    1988 Sep-Oct
Date Detail:
Created Date:  1988-11-02     Completed Date:  1988-11-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7703942     Medline TA:  J Comput Assist Tomogr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  721-7     Citation Subset:  IM    
Affiliation:
GEC Hirst Research Laboratories, Wembley, Middlesex, England.
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain / pathology
Brain Diseases / physiopathology*
Brain Neoplasms / physiopathology
Cerebral Infarction / physiopathology
Cerebrovascular Circulation*
Humans
Infant
Infant, Newborn
Intracranial Arteriovenous Malformations / physiopathology
Leukomalacia, Periventricular / physiopathology
Magnetic Resonance Imaging*
Meningitis / physiopathology
Multiple Sclerosis / physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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