Document Detail

Assessment of brain perfusion with MR imaging.
MedLine Citation:
PMID:  3170829     Owner:  NLM     Status:  MEDLINE    
A technique for assessing brain perfusion with magnetic resonance (MR) imaging is described. This technique uses two spin echo sequences that are identical except that the second is sensitised to blood flow by use of a pair of unipolar gradients on either side of the 180 degree pulse. Differences in phase between the two sequences are displayed with a sensitivity to flow rates of +/- 0.5, +/- 1, and +/- 2 mm/s per full scale (+/- pi radians) deflection. The technique was validated for measurement of flow at these rates with a water phantom. Ten patients with cerebrovascular disease, multiple sclerosis, cerebral tumor, periventricular leukomalacia, and meningitis were studied. Differences between grey and white matter were normally seen in adults. Infants displayed differences between central and peripheral regions of the brain. Abnormalities were seen in all clinical cases. The technique will require further validation but it appears to provide a totally noninvasive method for assessing brain perfusion.
I R Young; A S Hall; D J Bryant; D G Thomas; S S Gill; L M Dubowitz; F Cowan; J M Pennock; G M Bydder
Related Documents :
3082149 - Sequential mr studies of intracerebral hematomas in monkeys.
1917389 - Blood-retinal barrier breakdown investigated by real-time magnetic resonance imaging af...
7584229 - Black-blood and segmented k-space magnetic resonance angiography.
17677559 - Hydromagnetic instability in plane couette flow.
19428529 - Intracranial microprobe for evaluating neuro-hemodynamic coupling in unanesthetized hum...
16118549 - How to compare the efficiency of albumin-bound and nonalbumin-bound contrast agents in ...
6973469 - Cmro2 and cbf by the oxygen-15 inhalation technique. results in normal volunteers and c...
21928709 - Effect of lead on human erythrocytes: an in vitro study.
10052599 - Profile of neurohumoral agents on mesenteric and intestinal blood flow in health and di...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of computer assisted tomography     Volume:  12     ISSN:  0363-8715     ISO Abbreviation:  J Comput Assist Tomogr     Publication Date:    1988 Sep-Oct
Date Detail:
Created Date:  1988-11-02     Completed Date:  1988-11-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7703942     Medline TA:  J Comput Assist Tomogr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  721-7     Citation Subset:  IM    
GEC Hirst Research Laboratories, Wembley, Middlesex, England.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Brain / pathology
Brain Diseases / physiopathology*
Brain Neoplasms / physiopathology
Cerebral Infarction / physiopathology
Cerebrovascular Circulation*
Infant, Newborn
Intracranial Arteriovenous Malformations / physiopathology
Leukomalacia, Periventricular / physiopathology
Magnetic Resonance Imaging*
Meningitis / physiopathology
Multiple Sclerosis / physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Energy expenditure and protein turnover in three species of wallabies (Marsupialia: Macropodidae).
Next Document:  Gadolinium DTPA enhanced MR imaging of ACTH-secreting microadenomas of the pituitary gland.